Activated microglia are known to be a major source of cellular neuroinflammation which causes various neurodegenerative diseases, including Alzheimer's disease. In our continuing efforts to search for new bioactive phytochemicals against neuroinflammatory diseases, the 80% methanolic extract of Pteris multifida (Pteridaceae) roots was found to exhibit significant NO inhibitory activity in lipop...

In an out-of-court sum m er se ttle ­ m ent o f the Fresc and Ford sex dis­ crim ination lawsuits against the University, N otre Dame denied a his­ tory of discrim ination against female faculty in tenure and con tract deci­ sions. The University, how ever, did make substantial concessions to the plaintiffs The 16-page settlem ent, ap­ proved by U.S. District Judge Allen Sharp on July 31, consi...

Total syntheses of ent-penicillones A (ent-1) and B (ent-2) from 3,5-dimethylcatechol (3) were accomplished in 10 and 9 synthetic steps, respectively. A carbohydrate-templated asymmetric intramolecular Diels-Alder reaction of a masked o-benzoquinone (MOB) 9 and an aqueous acid-catalyzed intramolecular aldol reaction are the key synthetic steps. In addition, the absolute configurations of the bi...

صلاخلا ــ ة : مت ةقرولا هذه يف ءاشنإ يف هدعاسملل مدقتم ماظن بناوج ذيفنتو ميمصت ضرع قتو و مي ءادأ حيحصت تارفش لأا ءاطخ ةليلق لا ةناتم ، ةينبم ىلع ءوفاكتلا رايتخا . موقي امه نيتيسيئر نيتفيظوب ةساردلا هذه يف مدقتملا ماظنلا : 1 ادأ باسحل ةيزاوتملا هاآاحملا ء تارفش حيحصت لأا ءاطخ ةليلق نمزب ةفاثكلا ادج ريصق ةنراقم ةمظنأب ةاآاحملا ةدوجوملا . 2 ةليلق ءاطخلأا حيحصت تارفشو فعضلا قطانم صحف نع ة...

ent-Kaurene diterpenoids, phyllostachysins D-H (1-5), together with nine known compounds, rabdoloxins A-B (6-7), rabdoinflexin B (8), amethystoidin A (9), rabdokunmin D (10), macrocalyxin E (11), 5,7-dihydroxy-4'-hydroxylflavone (12), oleanolic acid (13) and daucosterol (14), were isolated from aerial parts of Isodon phyllostachys. Structures were elucidated on the basis of spectroscopic method...

Three novel compounds, together with five known ingredients, octacosanol, 3',4',5-trihydroxy-3,7-dimethoxyflavone, 3,4-dihydroxybenzaldehyde, isorhamnetin, and ent-kaurane-3beta,16beta,17-triol, were obtained from the leaves of Smallanthus sonchifolius (yacon), and their structures were elucidated as ent-kaurane-3beta,16beta,17,18-tertol (1), 3R,7E-9-butoxyl-megastigma-3-ol-3-O-beta-D-glucopyra...

BACKGROUND A high rate of resistance to 3rd generation cephalosporins among Enterobacteriaceae isolates from Egypt has been previously reported. This study aims to characterize the resistance mechanism (s) to extended spectrum cephalosporins among resistant clinical isolates at a medical institute in Cairo, Egypt. METHODS Nonconsecutive Klebsiella pneumoniae (Kp), Enterobacter cloacae (ENT) a...

2 3 Background: A high rate of resistance to 3 rd generation cephalosporins among Enterobacteriaceae 4 isolates from Egypt has been previously reported. This study aims to characterize the resistance 5 mechanism (s) to extended spectrum cephalosporins among resistant clinical isolates at a medical 6 institute in Cairo, Egypt. 7 Methods: Nonconsecutive Klebsiella pneumoniae (Kp), Enterobacter cl...

Background: The corona virus disease also known as COVID-19 has opened gates to a lot of research about detection, treatment and prevention in the last past year due lack information regarding SARS-CoV-2 virus. PCR via nasopharyngeal swab is standard method detection our set-up. Materials methods: Nasopharyngeal swabs were taken by ENT department using precautions following proper SOPs. Swabs s...