The preclinical evaluation of drugs, including environmental agents, depends on toxicology studies carried out in animals under defined in vivo and in vitro conditions. With the advancement of biological and analytical sciences, toxicology has become highly multidisciplinary involving cellular, biochemical and molecular technology. It is now mandatory to perform reproductive and genetic toxicol...

423 A k-NN Algorithm for Predicting Oral Sub-Chronic Toxicity in the Rat Domenico Gadaleta 1,2, Fabiola Pizzo 1, Anna Lombardo 1, Angelo Carotti 2, Sylvia E. Escher 3, Orazio Nicolotti 2 and Emilio Benfenati 1 laboratory of environmental Chemistry and toxicology, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy; Dipartimento di Farmacia − Scienze del Farmaco, Università degl...

KEITH R. SOLOMON,*y JOHN P. GIESY,z THOMAS W. LAPOINT,§ JEFFREY M. GIDDINGS,k and R. PETER RICHARDS# yCentre for Toxicology, School of Environmental Sciences, University of Guelph, Ontario, Canada zDepartment of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada §Department of Biological Sciences, University of North Texas, Denton, ...

In the desert Southwest, communities are slaking their thirst for knowledge with an outreach program that is overflowing with environmental health information. The Southwest Environmental Health Sciences Center (SWEHSC) at the University of Arizona in Tucson is one of 21 such centers that, along with 5 Marine and Freshwater Biomedical Sciences Centers and 1 Developmental Center, make up the 28 ...

CALIFORNIA ENVIRONMENTAL PROTECTION AGENCY DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA ORTHO-PHENYLPHENOL (OPP) AND SODIUM ORTHO-PHENYLPHENATE (SOPP) OPP: Chemical Code # 448, Document Processing Number (DPN) # 00129, SB 950 # 090 SOPP: Chemical Code # 248, Document Processing Number (DPN) # 50438, SB 950 # 474 July 29, 1986 Revised: 3/30/87, 8/30/89,...

*AstraZeneca, Safety Assessment Alderley Park, Macclesfield, Cheshire, SK10 4TG United Kingdom; †Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan MI 48824; ‡Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, Colorado CO 80262; §Department of Environmental Sciences and Engineering, University of North Carolina...

In early 2008, the National Institute of environmental Health Sciences/National toxicology Program, the NIH Chemical Genomics Center, and the environmental Protection Agency’s National Center for Computational toxicology entered into a Memorandum of Understanding to collaborate on the research, development, validation and translation of new and innovative test methods that characterize key step...

The purpose of this paper is to present some of the more carefully studied aspects of the preclinical toxicology of antineo-plastic agents, and apply these findings (with certain obvious cautions) to the area of environmental toxicology. Most of the studies to be described here are the result of applied toxicologic studies performed in support of the clinical introduction of new chemicals in th...

1. NTP. Toxicology and Carcinogenesis Studies of 60-Hz Magnetic Fields in F344/N Rats and B6C3F1 Mice (Whole-Body Exposure Studies)-Draft. Research Triangle Park, NC:National Toxicology Program, 1998. http://ehis.niehs.nih.gov/ntp/docs/tr488/488full.pdf [cited 11 March 19981. 2. Frey AH, ed. On the Nature of Electromagnetic Field Interactions with Biological Systems. Austin, TX:R.G. Landes Co.,...

The rapid onset of the science and experimental tools of molecular biology and genomics has presented the toxicology community with an unprecedented opportunity to reexamine, and potentially significantly restructure, many of the decadeslong principles and practices guiding translation of conventional animal toxicology data to scientifically informed assessments of adverse human health risks. I...