A 6-year-old boy with focal seizures and headache. Diagnostic imaging demonstrated a right subcortical parietooccipital heterogeous expansive lesion, with growth into the adjacent ventricular system (Fig 1). Histological analysis led to the diagnosis of tanycytic ependymoma, as tumor cells have features resembling tanycytes (Fig 2). More than half of these tumors occur in the spinal cord. Supra...

Ependymomas are the commonest type of spinal glioma which represent a group of relatively benign tumours. Myxopapillary ependymoma (MPE) is a common variant found within the distal spinal cord around the conus. These two entities are clearly differentiated on the basis of their characteristic histological and molecular features. Rare variants of MPE's are described in the literature to have the...

intradural tumors (WHO grade I) that characteristically occur in the conus medullaris/filum terminale region. They are slow growing tumors with a good prognosis and long-term survival.1 We report a rare case of double MPE occurring at both extremities of the filum terminale. In the light of the present case and an extensive review of the literature, we summarize the imaging characteristics and ...

Background After surgery and radiation, treatment options for ependymoma are few making recurrence a challenging issue. Specifically, the efficacy of chemotherapy at recurrence is limited. We performed molecular profiling on a cohort of ependymoma cases in order to uncover therapeutic targets and to elucidate the molecular mechanisms contributing to treatment resistance. Results This ependymo...

OBJECT Previous small studies disagree about which clinical risk factors influence ependymoma incidence. The authors analyzed a large, population-based cancer registry to examine the relationship of incidence to patient age, sex, race, and tumor location, and to determine incidence trends over the past 3 decades. METHODS Data were obtained from the Surveillance, Epidemiology, and End Results ...

BACKGROUND Imaging and histology of clear-cell ependymoma and cerebellum-based hemangioblastoma are similar; distinguishing between them is a diagnostic challenge. CASE PRESENTATION A 62-year-old Chinese woman presented with an intermittent headache of 8 years' duration. Computed tomography and magnetic resonance imaging revealed a mass in the cerebellum. Neurological imaging suggested hemang...