OBJECTIVE Little is known about the incidence of secondary neoplasms among survivors of retinoblastoma in Japan. The objective of our study was to analyze the cumulative incidence rate of secondary neoplasms following retinoblastoma and to investigate the risk factors of developing secondary neoplasms. METHODS We conducted a retrospective cohort study of 754 retinoblastoma patients who visite...

There is considerable debate about the significance of choroidal invasion of retinoblastoma with regard to metastatic disease. The charts of patients with retinoblastoma were reviewed over a 17 year period to determine the frequency of histopathological choroidal invasion of retinoblastoma and its risk for eventual metastatic disease. Sixty seven of 289 eyes (23%) enucleated for retinoblastoma ...

The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially expressed (DE) genes, and clusters were obtained through the molecular ...

IMPORTANCE Most children with retinoblastoma in the United States are diagnosed as having a large intraocular tumor burden that requires intensive ocular-salvage treatment or enucleation. OBJECTIVE To investigate the effect of socioeconomic status, race, and ethnicity on the extent of disease and the outcomes of retinoblastoma. DESIGN, SETTING, AND PARTICIPANTS A population-based review of ...

Incidence of orbital tumor is -3.5-4%. Tumors and tumorlike lesions of the orbit in children represent a different histologic spectrum than in adults. In the pediatric population, a delay in diagnosis of orbital tumors, even if benign, can lead to vision loss and deformity. Purpose of this study is presentation of epidemiology, clinical signs and symptoms, frequency and histopathology of orbita...

There is little information about the epidemiology of congenital eye anomalies in Ghana. We retrospectively reviewed the clinical records of 485 admissions to the paediatric eye centre of the Korle-Bu Teaching Hospital, Ghana (2004-2009) and 263 were diagnosed with at least one anomaly. Visual acuity was quantitatively assessed in 209 patients and 130 had some visual impairment; 49 with bilater...

background: burn injuries are a major public health in the world, especially in developing countries. the aim of this study was investigate to the epidemiological data and cost of hospitalization due to burn in pediatrics in kermanshah provinces from 2011 to 2013.material and methods: this was a retrospective cross sectional study. the study subject was all of patient lee than 15 years who admi...

Inactivating mutations of the retinoblastoma susceptibility gene (Rb) are involved in the pathogenesis of hereditary and sporadic retinoblastoma. Alterations in the Rb gene have also been found in several other human tumors occurring with epidemiological incidence higher than that of retinoblastoma. Four human malignant glioma cell lines were examined for abnormalities in the retinoblastoma gen...

1Ophthalmologist, Medical Doctor specializing in ocular oncology, Ophtalmology Department at Hospital A.C.Camargo, São Paulo, SP, Brazil 2Medical Doctor specialized in Pediatrics, Pediatrics Department, Hospital A.C.Camargo, São Paulo, SP, Brazil 3Ophthalmologist, Ophtalmology Department at Hospital A.C.Camargo, São Paulo, SP, Brazil 4Ophthalmologist, Head of the Ophtalmology Department at Hosp...