نتایج جستجو برای: epithelial neoplasia

تعداد نتایج: 180290  

Journal: :Cancer research 2005
Xiaoqian Ma Angelique C Ziel-van der Made Binha Autar Hetty A van der Korput Marcel Vermeij Petra van Duijn Kitty B Cleutjens Ronald de Krijger Paul Krimpenfort Anton Berns Theo H van der Kwast Jan Trapman

The PTEN tumor suppressor gene is frequently inactivated in human tumors, including prostate cancer. Based on the Cre/loxP system, we generated a novel mouse prostate cancer model by targeted inactivation of the Pten gene. In this model, Cre recombinase was expressed under the control of the prostate-specific antigen (PSA) promoter. Conditional biallelic and monoallelic Pten knock-out mice were...

2011
Patrick Laprise

Defects in apical-basal polarity regulation are associated with tissue overgrowth and tumorogenesis, yet the molecular mechanisms linking epithelial polarity regulators to hyperplasia or neoplasia remain elusive. In addition, exploration of the expression and function of the full complement of proteins required for the polarized architecture of epithelial cells in the context of cancer is await...

Journal: :International Journal of Clinical Oncology and Cancer Research 2018

2018
Takayuki Shiraki Hajime Kuroda Atsuko Takada Yoshimasa Nakazato Keiichi Kubota Yasuo Imai

AIM To evaluate the usefulness of frozen section diagnosis (FSD) of bile duct margins during surgery for extrahepatic cholangiocarcinoma (CCA). METHODS We retrospectively analyzed 74 consecutive patients who underwent surgery for extrahepatic CCA from 2012 to 2017, during which FSD of bile duct margins was performed. They consisted of 40 distant and 34 perihilar CCAs (45 and 55 bile duct marg...

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