نتایج جستجو برای: epothilone a
تعداد نتایج: 13431870 فیلتر نتایج به سال:
A diverse group of natural biological compounds bind to microtubules and suppress microtubule dynamics. Here we review the mechanism of microtubule assembly and dynamics as well as structural features that are important for nucleotide binding, GTP hydrolysis and stabilization of longitudinal and lateral protofilament contacts. Specific emphasis is placed upon the polar structure of the microtub...
Two prostaglandins, PGA2 and PGB2, were isolated from the Okinawan zoanthid, Palythoa kochii, during a search for paclitaxel-like neurite-degenerating compounds from natural sources using a cell-based assay method. In the presence of PGA2 at 30 microM, the neuronal processes induced in PC12 cells by the nerve growth factor (NGF) degenerated over 24 h, whereas PGB2 had no effect on the neuronal ...
Studies indicate that diabetics are more likely to develop cancer, especially of the pancreas or colon, or hepatocellular carcinoma. Tumor genesis is promoted by high insulin and glucose levels pancreas, in T2DM (Saito et al., 2013; Zheng et al., 2013; Wang et al., 2015). Metformin, a commonly used drug for T2DM, reduces the incidence of various types of neoplasm. However, much less is known ab...
BACKGROUND Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development of new and more potent anti-HIV drugs. Here we established a high-throughput screen based on the highly permissive TZM-bl cell line to identify novel HIV inhibitors....
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