Six different 1,2-epoxycycloalkanes, whose rings were constituted of 5 to 12 carbon atoms, were tested as possible inhibitors of epoxide-metabolizing enzymes and substrates for the microsomal and cytosolic epoxide hydrolases (mEH, cEH) in mouse liver. The geometric configurations and the relative steric hindrances of these epoxides were estimated from their ease of hydrolysis in acidic conditio...

Epoxides are organic three-membered oxygen compounds that arise from oxidative metabolism of endogenous, as well as xenobiotic compounds via chemical and enzymatic oxidation processes, including the cytochrome P450 monooxygenase system. The resultant epoxides are typically unstable in aqueous environments and chemically reactive. In the case of xenobiotics and certain endogenous substances, epo...

Metabolism of trans-7,8-dihydroxy-7,8-dihydro-6-fluorobenzo(a)pyrene by liver microsomes from 3-methylcholanthrene-treated rats and by a highly purified monooxygenase system, reconstituted with cytochrome P-450c, has been examined. Although both the fluorinated and unfluorinated 7,8-dihydrodiol formed from benzo(a)pyrene by liver microsomes share (R,R)-absolute configuration, the fluorinated di...

Molybdate ionic liquids active for CO 2 fixation into terminal and internal epoxides without any added halide co-catalysts are described. 95 Mo-NMR spectra demonstrate the interaction activation of with MoO 4 species.

In situ hydrolyzed acetals were coupled with in situ generated allyl boronates in a one-pot procedure, affording regio- and stereodefined homoallyl alcohols, epoxides and amino alcohols.

bon. Recent studies have shown that little if any B(e)P3(Chart i ) is metabolized to B(e)P 9,i 0-dihydrodiol by cultured hamster embryo cells (i 5) and rat liver microsomes,4 and little if any B(e)P dihydrodiol is metabolized to its bay-region diol-epoxide diastereomers by rat liver microsomes (i 2, 28). While the reason for the negligible amount of B(e)P 9, 10-dihydrodiol formation has not bee...

A hyperresponsive tool to assess supramolecular catalysis, the cyclization of di-epoxides into cyclic ethers is used elucidate difference between pnictogen-bonding and Lewis acid catalysis systematically. For all stereoisomers, most tested catalysts follow Baldwin rules. Brønsted anion–? afford almost only products. acids such as SbCl3, BF3 BiCl3 give poorest selectivity, with at least 50 % (B)...

Aliphatic polyesters constitute an important class of polymers because of their biodegradability1,2 and biocompatability,2,3 which enable their use in drug delivery systems,2 artificial tissues,3 and commodity materials.4 Polyesters such as poly(butylene succinate) are commonly produced through condensation polymerization; however, this method is energy intensive, requiring high temperature and...

Previous studies have identified allelic variants of the human glutathione transferase (GST) Pi gene and showed that the two different encoded proteins with isoleucine (GSTP1-1/I-105) or valine (GSTP1-1/V-105) at position 105, respectively, differ significantly in their catalytic activities with model substrates. Moreover, recent epidemiological studies have demonstrated that individuals differ...

Organoboron catalysts including an ammonium salt separated by a few carbon–carbon bonds to boron center were designed and synthesized. Borinane-based organoboron exhibited highest activity for the copolymerization of CO 2 epoxides.