Soft injuries present a significant clinical and research challenge to biological and medical doctors. The search for a successful long-term solution remains the focus of intense research. Over the past few years, several exciting technologies have emerged, which, given time, may provide a realistic clinical management option. This issue represents the synthesis of the philosophy of I.S.Mu.L.T....

Recently, studies focused on mesenchymal stem/stromal cells (MSCs) as progenitor cells due to their capacity to regenerate mesodermal tissues such as cartilage, adipose and bone. However, there are practical and ethical challenges regarding the isolation of these cells from different sources (mainly bone marrow). The ability to produce MSCs from human embryonic stem cells (hESCs) could be valua...

Mesenchymal stem cells (MSCs) are progenitors of all connective tissue cells. In adults of multiple vertebrate species, MSCs have been isolated from bone marrow (BM) and other tissues, expanded in culture, and differentiated into several tissue-forming cells such as bone, cartilage, fat, muscle, tendon, liver, kidney, heart, and even brain cells. Recent advances in the practical end of applicat...

Title of Document: MESENCHYMAL STEM CELL ENRICHMENT AND DIFFERENTIATION THROUGH FUNCTIONALIZED BIOMATERIALS Kimberly Marie Ferlin, Doctor of Philosophy, 2015 Directed By: John P. Fisher, Ph.D., Fischell Family Distinguished Professor Fischell Department of Bioengineering The use of mesenchymal stem cells (MSCs) for tissue engineering and cellbased therapies has great potential. MSCs are an adul...

Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone marrow. However, subsequent research has shown that other adult tissues also contain MSCs. MSCs originate from mesenchyme, which is embryonic tissue derived from the mesoderm. These cells actively proliferate, giving rise to new cells in some tissues, but remain quiescent in others. MSCs are capable of dif...

Persephin (PSPN) is one of the neurotrophic factors of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which have been found to promote the survival of specific populations of neurons. The aim of this study was to assess the potential therapeutic function of gene-modified mesenchymal stem cells (MSCs)-Lv-PSPN-MSCs in 6-OHDA-induced Parkinson's disease (PD) rats mode...

Mesenchymal stem cells (MSCs) are non-hematopoietic progenitor cells, which can be isolated from different types of tissues including bone marrow, adipose tissue, tooth pulp, and placenta/umbilical cord blood. There isolation from adult tissues circumvents the ethical concerns of working with embryonic or fetal stem cells, whilst still providing cells capable of differentiating into various cel...

Equine influenza is a cause of epizootic respiratory disease of the equine. The detection of equine influenza virus using real-time Light Cycler reverse transcription (RT)-PCR technology was evaluated over two influenza seasons with the analysis of 171 samples submitted for viral respiratory disease. Increased sensitivity was found in overall viral detection with this system compared to Directi...

Background Mesenchymal stem cells (MSCs) have gained much attention for their potential to treat osteoarthritis (OA) due regenerative and immunomodulatory properties. So far, studies shown varying results, potentially variations in the MSC preparations. Previously it was that integrin α10β1-selected equine MSCs (integrin α10-MSCs) decrease cartilage degradation bone sclerosis an experimental po...