نتایج جستجو برای: erk

تعداد نتایج: 21373  

Journal: :The EMBO journal 2006
Myungjin Kim Jun Hee Lee Hyongjong Koh Soo Young Lee Cholsoon Jang Cecilia J Chung Jung Hwan Sung John Blenis Jongkyeong Chung

Although p90 ribosomal S6 kinase (RSK) is known as an important downstream effector of the ribosomal protein S6 kinase/extracellular signal-regulated kinase (Ras/ERK) pathway, its endogenous role, and precise molecular function remain unclear. Using gain-of-function and null mutants of RSK, its physiological role was successfully characterized in Drosophila. Surprisingly, RSK-null mutants were ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Lisa K McNeil Timothy K Starr Kristin A Hogquist

It is unknown how the contrasting events of positive and negative selection can lead to the distinct biological outcomes of life or death. An increasing body of evidence suggests that the duration of extracellular signal-regulated kinase (ERK) signaling plays a role in thymocyte selection. However, it remains unclear what the kinetics of ERK activation are during positive selection in vivo. In ...

Journal: :Cancer research 2007
Janiel M Shields Nancy E Thomas Melissa Cregger Aaron J Berger Michael Leslie Chad Torrice Honglin Hao Shannon Penland Jack Arbiser Glynis Scott Tong Zhou Menashe Bar-Eli James E Bear Channing J Der William K Kaufmann David L Rimm Norman E Sharpless

The majority of human melanomas harbor activating mutations of either N-RAS or its downstream effector B-RAF, which cause activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase and the ERK MAPK cascade. The melanoma-relevant effectors of ERK activation, however, are largely unknown. In this work, we show that increased ERK activation correlates ...

Journal: :The EMBO journal 2006
Claire Letourneux Géraldine Rocher Françoise Porteu

The protein phosphatase 2A (PP2A) acts on several kinases in the extracellular signal-regulated kinase (ERK) signaling pathway but whether a specific holoenzyme dephosphorylates ERK and whether this activity is controlled during mitogenic stimulation is unknown. By using both RNA interference and overexpression of PP2A B regulatory subunits, we show that B56, but not B, family members of PP2A i...

2018
Dongjie Li Yutao Wei Shangzhi Xu Qiang Niu Mei Zhang Shugang Li Mingxia Jing

Arsenic is a toxic metal, which ultimately leads to cell apoptosis. ERK is considered a key transcriptional regulator of arsenic‑induced apoptosis. Due to a few controversial issues about arsenic‑mediated extracellular signal‑regulated MAP kinases (ERK) signaling, a meta‑analysis was performed. Subgroup analyses demonstrated that high doses (≥2 µmol/l) of arsenic increased the expression of Ras...

Journal: :Journal of neurochemistry 2007
Qiu-Lan Ma Marni E Harris-White Oliver J Ubeda Mychica Simmons Walter Beech Giselle P Lim Bruce Teter Sally A Frautschy Greg M Cole

Extracellular-signal regulated kinase (ERK) signaling is critical for memory and tightly regulated by acute environmental stimuli. In Alzheimer disease transgenic models, active ERK is shown to first be increased, then later reduced, but whether these baseline changes reflect disruptions in ERK signaling is less clear. We investigated the influence of the familial Alzheimer's disease transgene ...

Journal: :Current Biology 2005
Sean W. Deacon Alexandra Nascimento Anna S. Serpinskaya Vladimir I. Gelfand

Regulation of intracellular transport plays a role in a number of processes, including mitosis, determination of cell polarity, and neuronal growth. In Xenopus melanophores, transport of melanosomes toward the cell center is triggered by melatonin, whereas their dispersion throughout the cytoplasm is triggered by melanocyte-stimulating hormone (MSH), with both of these processes mediated by cAM...

Journal: :Current Biology 2016
Ravi Ranjan Pragya Gupta Arun K. Shukla

β-arrestin-dependent activation of the ERK MAP kinase downstream of GPCRs typically originates from internalized receptor-β-arrestin-ERK complexes. A new study now reports that β-arrestin 2 is sufficiently 'primed' after 'kissing' the β1-adrenergic receptor to initiate ERK activation even in the absence of formation of the receptor-β-arrestin-ERK complex and receptor internalization.

Journal: :Cancer research 2006
Michael Schümann Matthias Dobbelstein

The Raf/mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK signaling cascade enhances tumor cell proliferation in many cases. Here, we show that adenovirus type 5, a small DNA tumor virus used in experimental cancer therapy, strongly induces ERK phosphorylation during the late phase of infection. Pharmacologic inhibition of ERK phosphorylation reduced virus r...

Journal: :Journal of Food Biochemistry 2023

Isochlorogenic acid C (ICAC) is found in a variety of natural foods and medicinal plant materials. This study aims to validate the biological activity isochlorogenic limiting inflammation by Erk/JNK/NF-κB pathway. In this study, TNF-α-induced human fibroblast-like synoviocytes collagen-induced arthritis animal models were used perceive potential anti-inflammation mechanism ICAC. The role was ev...

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