Anemia is a frequent complication in the maintenance hemodialysis (MHD) patients. However, data on serum hepcidin level as a guide in MHD patients are limited. We aimed to investigate the clinical significance of serum hepcidin level on erythropoiesis-stimulating agents (ESAs) and/or intravenous iron therapy among MHD patients. A total of 32 MHD patients receiving ESAs and iron therapy were enr...

OBJECTIVE Evaluation of the presence of symptoms and suitability in the treatment of patients admitted to medical wards at HU-UFSC. Identification of patients eligible for palliative care (PC). METHOD A prospective cohort study, which evaluated patients in the first 48 hours of hospitalization (D1) and after 48 hours (D2). On D1, palliative performance and symptom assessment scales were appli...

Cancer and its treatments—including surgery, chemotherapy, radiation, and hormone therapy—are associated with decreased physical function and adverse psychological and emotional effects. Physical symptoms commonly include fatigue, nausea, pain, and decreased strength and endurance1–4. The importance of appreciating the consequences of cancer-related side effects is magnified as the number of pe...

Over the past few decades, understanding of the physiologic function of erythropoietin (EPO) has evolved significantly. EPO binds to erythropoietin receptors (EPOR), initiating signaling that stimulates growth, inhibits apoptosis, and induces the differentiation of erythroid progenitors to increase red blood cell mass. EPO has additionally been shown to exert tissue-protective effects on multip...

BACKGROUND The issue of how to address patient pain in the outpatient setting remains challenging. At the London Regional Cancer Program (London, Ontario), patients complete the Edmonton Symptom Assessment System (ESAS) before most visits. OBJECTIVES To perform a chart review assessing the frequency and, if applicable, the type of a clinical care plan that was developed if a patient indicated...

La identificación las prácticas de Ingeniería de Requerimientos (RE) en la comunidad de desarrollo de software es un aspecto clave para la orientación de las investigaciones y el desarrollo de las actividades académicas en general. En particular la evolución de esas prácticas es una herramienta de orientación en proyectos nuevos de investigación. Si bien se dispone de ejemplos de estudio de las...

The PROCLEIX West Nile virus assay (WNV assay) is a qualitative nucleic acid test based on transcription-mediated amplification (TMA). The assay was used under an investigational protocol in the United States to screen blood donations for West Nile virus (WNV) RNA starting in the summer of 2003, and was licensed by the FDA in December 2005 for use on the PROCLEIX System, also known as the enhan...

Treatment with erythropoiesis-stimulating agents (ESAs) enables the correction of anaemia in chronic kidney disease (CKD) patients, thus reducing its symptoms and complications. Not only is iron therapy aimed at correcting iron deficiency, but also it is an adjuvant therapy in CKD patients receiving ESAs. Iron stores in CKD patients may be near normal, but there may be insufficient immediately ...

The NASA Exploration Systems Architecture Study (ESAS) produced a transportation architecture for returning humans to the moon affordably and safely. ESAS determined that the best lunar exploration strategy was to separate the launch of crew from the launch of cargo, thereby requiring two launches per lunar mission. An alternate concept for the cargo launch vehicle is a side mounted Shuttle-der...

Comparative studies of the potency of long- and short-acting erythropoiesis-stimulating agents (L-ESAs and S-ESAs) on erythropoietic activity in patients with chronic kidney disease without dialysis have not been performed, although L-ESAs are used in many countries. We performed a retrospective analysis of non-dialysis (ND) patients who had received L-ESA or S-ESA. More days were needed for th...