Methods Objective: The objective of the study was to investigate the effect of the short-acting β-blocker esmolol in patients with severe septic shock. Design: An open-label, randomized phase 2 study was conducted between November 2010 and July 2012. Setting: The study was conducted in a university hospital ICU. Subjects: Patients were in septic shock with a heart rate of 95/minute or higher re...

Background & Objectives: Direct laryngoscopy and endotracheal intubation always trigger powerful cardiovascular responses. It may be well tolerated in healthy people, but hazardous patients with hypertension, tachycardia, myocardial infarction, other complications.Various attempts have been made to attenuate these The present study has undertaken make a comparative of both drugs Esmolol Magnesi...

OBJECTIVE A comparative study to evaluate the efficacy of dexmedetomidine as a hypotensive agent in comparison to esmolol in Functional Endoscopic Sinus Surgery (FESS). METHODS Forty patients ASA I or II scheduled for FESS were equally randomly assigned to receive either dexmedetomidine 1 μg/Kg over 10 min before induction of anesthesia followed by 0.4-0.8 μg/Kg/h infusion during maintenance ...

Background—High catecholamine concentrations are cytotoxic to cardiac myocytes. We hypothesized that myocardial interstitial catecholamine levels are greatly elevated immediately after long-duration ventricular fibrillation (VF), defibrillation, and reperfusion and that the short-acting -antagonist esmolol administered at reperfusion would protect against this catecholamine surge and improve su...

OBJECTIVE To compare the effects of esmolol and remifentanil, used as adjuncts for induced hypotension on surgical conditions and short-term cognitive functions, during tympanoplasty. METHODS The study was conducted in Hacettepe University, School of Medicine, Ankara, Turkey between January 2005 and December 2006 following Institutional Ethical Committee approval, 40 ASA I-II patients, betwee...

OBJECTIVE This study aimed to evaluate the efficacy of flecainide therapy in neonates and infants with drug resistant incessant supraventricular tachycardia. METHODS The study included 11 neonates and infants who received medical and/or ablation therapy between January 2010 and December 2013. Mean patient age and weight were 101.6 ± 96 days and 5.3 ± 1.9 kg respectively. Of the 12 patients, 5...