To determine the relationship between baseline impedance levels and gastroesophageal reflux, we retrospectively enrolled 110 patients (54 men and 56 female; mean age, 51 ± 14 years) with suspected gastroesophageal reflux disease (GERD) who underwent 24-h multichannel intraluminal impedance and pH monitoring. Patients were stratified according to symptom (typical or atypical) and reflux types (a...

Gastroesophageal reflux disease (GERD) is the main etiological factor behind the recent rapid increase in the incidence of esophageal adenocarcinoma. During reflux, esophageal cells are exposed to bile at low pH resulting in cellular damage and inflammation, which are known to facilitate cancer development. In this study, we investigated the regulation of p73 isoform, ΔNp73α, in the reflux cond...

TO THE EDITOR: I read with great interest the paper entitled “Gastroesophageal reflux disease in type II diabetes mellitus with or without peripheral neuropathy” by Lee et al, which was published in July 2011 issue of Journal of Neurogastroenterology and Motility. The authors investigated gastroesophageal reflux disease (GERD) among patients with type II diabetes mellitus, and showed interestin...

Background: Gastro-esophageal reflux disease (GERD) is believed to be a common cause of chronic cough. There paucity data on GERD-related cough (GERC) from Singapore. Our aim was examine the prevalence, demographics and clinical features GERC patients seen in large teaching hospital Singapore.Methods: We did retrospective review referred respiratory clinic for evaluation (≥ 6 weeks duration). A...

Background: feeding/eating disorders are frequent in pediatric patients and, in some cases, can be associated to an upper digestive motility disorder. Gastro-esophageal reflux is, nowadays, considered a risk factor for the development of feeding/eating disorders. Aim: to verify the occurrence of feeding/eating disorders in patients with Gastro-Esophageal Reflux Disease (GERD) determined by the ...

Analyzing medical issues related to the elderly patients, particularly in the gastroenterological sphere, Gastro-Esophageal Reflux Disease (GERD) seems to be a disease that reaches an important role in terms of diagnosis and therapy, as well as adversely affect the quality of life of these “frail” patients. Comorbidities that affect these patients often lead to reduce the importance of this dis...

Recognizing nonerosive reflux disease (NERD) as a distinct presentation of gastroesophageal reflux disease (GERD) was one of the most important developments in the field of GERD in the last decade. Whilst the definition of NERD has not changed significantly over the years, the disorder accounts for the majority of the GERD patients and those who failed proton pump inhibitor (PPI) treatment. Rec...

BACKGROUND In our previous case report of circumferential mucosal resection for short-segment Barrett's esophagus with high-grade dysplasia, symptoms of gastro-esophageal reflux disease (GERD) were significantly improved. This observation suggests that anti-reflux mucosectomy (ARMS) could represent an effective anti-reflux procedure, with the advantage that no artificial devices or prostheses w...

Gastro-esophageal reflux disease (GERD) in otherwise healthy older children and adolescents is commonly encountered in pediatric clinics and poses a complex treatment problem involving changes of diets and lifestyle. After an initial history taking and a physical examination, typical symptoms of GERD in older children and adolescenct are initially treated with the trials of acid suppressants. W...

Gastroesophageal reflux disease (GERD) is the main known etiological factor for Barrett’s esophagus (BE), and BE is the precursor lesion of esophageal adenocarcinoma. The prevalence of BE is reported mostly from gastroenterology centers and there are only a few reported cases from outpatients with dyspepsia. A large number of patients with GERD have degrees of dyspepsia. This study primarily ai...