Axons in the developing nervous system are directed via guidance cues, whose expression varies both spatially and temporally, to create functional neural circuits. Existing methods to create patterns of neural connectivity in vitro use only static geometries, and are unable to dynamically alter the guidance cues imparted on the cells. We introduce the use of AC electrokinetics to dynamically co...

Three fatty acids were separated by micellar electrokinetic chromatography (MEKC) using ammonium perfluorooctanoate as volatile surfactant. Characterizations of both injection buffer and background electrolyte have been performed complementary techniques including scattering experiments (light, x-rays) NMR. Different structures observed such small micelles at low methanol content larger aggrega...

We introduce a method for the numerical determination of the steady-state response of complex charged porous media to pressure, salt concentration, and electric potential gradients. The macroscopic fluxes of solvent, salt, and charge are computed within the framework of the Pore Network Model (PNM), which describes the pore structure of the samples as networks of pores connected to each other b...

Chemical structure of zinc in the electrokinetic treatments of an electroplating sludge has been studied by in situ extended X-ray absorption fine structural (EXAFS) and X-ray absorption near edge structural (XANES) spectroscopies in the present work. The least-square fitted XANES spectra indicate that the main zinc compounds in the sludge were ZnCO(3) (75%), ZnOSiO(2) (17%) and Zn(OH)(2) (7%)....

short timeframe, and rapid approaches are needed to assess log Pow values of these compounds (2,4,7). Several separation-based approaches for indirectly determining log Pow values in a rapid fashion have been reported, including reversed-phase high performance liquid chromatography (HPLC) (2,3,8–11), thin-layer chromatography (12,13), micellar electrokinetic chromatography (MEKC) (7,14–16), and...

Recent developments in the electrokinetic determination of particle, protein and polyelectrolyte monolayers at solid/electrolyte interfaces, are reviewed. Illustrative theoretical results characterizing particle transport to interfaces are presented, especially analytical formulae for the limiting flux under various deposition regimes and expressions for diffusion coefficients of various partic...

The requirement to boost the resolution of nanopore-based biosequencing devices necessitates integration novel biosensing techniques with reduced sensitivity background noise. In this article, we probe signatures translocating polymers in magnetic fields induced by ionic currents through membrane nanopores. Within framework a previously introduced charge transport theory, evaluate field signals...

Among the different types of DNA damage that occur endogenously in the cell, depurination is especially prevalent. These lesions can initiate mutagenesis and have been implicated in a variety of diseases, including cancer. Here, we demonstrate a new approach for the detection of depurination at the single-molecule scale using solid-state nanopores. We induce depurination in short duplex DNA usi...