The influence of gender on serum concentrations of growth hormone (GH) and 12 other endocrine analytes was investigated in sera drawn from 291 healthy medical students in the ambulatory state in the morning, after fasting overnight. GH was measured with a sensitive noncompetitive fluoroimmunoassay. The median GH value was 80-fold higher in women 21-26 years old than in age-matched men (14.4 vs ...

Background: Breast cancer is a hormone-dependent malignancy that is associated with estrogen and progesterone interactions. The liver is the most important organ to be affected by the metastasis of breast cancer, which causes functional impairment. We compared levels of obesity, 17β-estradiol, and secreted proteins in postmenopausal women with breast cancer but without hepatic symptoms to those...

background: in the present study the effects of a hydro-alcoholic saffron (crocus sativus) extract on pituitary-ovary axis and folliculogenesis were investigated. the aim was to study the possible role of saffron in female fertility and thereby show its usefulness in treating infertility and reproductive disorders in females. materials and methods: the study consisted of 50 adult female sprague...

The steroidogenic lesion produced in Leydig cells by gonadotropin stimulation has been attributed to an inhibitory effect of estrogen on 17a-hydroxylase and 17,20-desmolase activity, with impaired conversion of progesterone to androgens. In animals treated with doses of human chorionic gonadotropin (hCG) or gonadotropin-releasing hormone (GnRH) that caused the decrease in desmolase activity, ad...

Emerging research has demonstrated that the sex hormone estradiol regulates fear extinction in female rodents and women. Estradiol may also regulate fear extinction in males, given its role in synaptic plasticity in both sexes. Here we report that inhibition of estradiol synthesis during extinction training, via the aromatase inhibitor fadrozole, significantly impairs extinction recall in male ...

Annotation. The article presents the results of an experimental study dynamics changes in main female sex hormones with serial use doxorubicin. experiments were performed on 45 adult white rats. levels antimullerian hormone, estradiol and follicle-stimulating hormone studied. In total, 4 courses chemotherapy interval 3 weeks. After each course chemotherapy, hormonal status animals was studied t...

OBJECTIVE Diagnosis of central precocious puberty has always been challenging in clinical practice. As an important method in the diagnosis of central precocious puberty, luteinizing hormone-releasing hormone stimulation test is complex and time-consuming. In many cases, clinical traits are inconsistent with luteinizing hormone-releasing hormone stimulation test results, therefore not reliable ...

Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether hormones are associated with disease severity in COVID-19 patients. In this study, we analysed hormone levels (estradiol testosterone) of male female patients (n = 50) admitted to an unit (ICU) comparison control non-COVID-19 at the ICU 42), most prevalent comorbidity (...

BACKGROUND While elevated levels of estradiol were predictive of mortality in critically ill surgical and trauma patients, their ability to predict outcome in nonsurgical patients has not been studied. We aimed to study the determinants of gonadotropin levels in acutely ill postmenopausal women with nonsurgical disease and the impact of changes in the gonadal axis on the outcome of these patien...

The objective: to study the concentration of estradiol, progesterone, follicle-stimulating and luteinizing hormones, testosterone, prolactin cortisol in women with abnormal uterine bleeding (AUB) chronic psycho-emotional stress.Materials methods. We examined 100 reproductive age AUB stress (main group) 50 patients without (comparison group). 30 were included control group. diagnosis was made on...