Idiopathic systemic capillary leak syndrome (SCLS) is a rare and potentially fatal vascular disorder characterized by reversible bouts of hypotension and edema resulting from fluid and solute escape into soft tissues. Although spikes in permeability-inducing factors have been linked to acute SCLS flares, whether or not they act on an inherently dysfunctional endothelium is unknown. To assess th...

Endothelin (ET)-1 and its receptors (ETA and ETB receptor) are present in the central nervous system. ET exerts biological effects on gliogenesis and glial cell functions. In order to define a possible mechanism of ETA receptor signaling, the distribution of the ETA receptor in developing oligodendrocytes and the effects of ET-1 on the myelination of oligodendrocytes were examined. ETA receptor...

The Eta-1 gene specifies a secreted product of activated T cells and is associated with genetic resistance to infection by an obligate intracellular bacterium. Previous studies have suggested that eta-1 might affect the ability of macrophages to migrate to the site of bacterial infection and/or to inhibit intracellular bacterial growth. We therefore examined the interaction of eta-1 with macrop...

Analysis of RNA isolated from Pseudomonas aeruginosa PA103 and PAKS grown under Fe2+-limiting (0.08 microgram/ml) and Fe2+-sufficient (10 micrograms/ml) conditions demonstrated that exotoxin A (ETA) expression is regulated by Fe2+ at the level of transcription. S1 nuclease mapping revealed two 5' termini of the tox transcript, 89 base pairs (bp) (S1A) and 62 bp (S1B) 5' to the ETA initiation co...

We describe a murine cDNA, designated Early T lymphocyte activation 1 (ETA-1) which is abundantly expressed after activation of T cells. Eta-1 encodes a highly acidic secreted product having structural features of proteins that bind to cellular adhesion receptors. The Eta-1 gene maps to a locus on murine chromosome 5 termed Ric that confers resistance to infection by Rickettsia tsutsugamushi (R...

Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs, including ethionamide (ETA). ETA is a prodrug bioactivated by mycobacterial and mammalian flavin-containing monooxygenases (FMOs). FMO2 is the major isoform in the lungs of most mammals, including primates. In humans a polymorphism exists ...

THE VISCOSITY OF A COMPRESSED GAS IS A FUNCTION OF THREE VARIABLES: (1) the degree of crowding of the molecules; (2) their capacity, by reason of softness, flexibility, or rotational inertia, to absorb the vector momentum applied to cause flow; (3) the resistance to this vector momentum offered by the randomly oriented thermal momenta, which becomes significant when the liquid expands sufficien...

This study examines the effects of English training abroad (hereafter ETA) on labor market outcomes in South Korea. ETA has become increasingly popular in many non-English speaking countries and refers to short-term language study training abroad where students spend anywhere from 6 months to 2 years taking language courses at an educational institutions. In this article, I conduct survival ana...

In this paper, new concepts of monotonicity, namely (Φ, ρ)-monotonicity, (Φ, ρ)-pseudo-monotonicity and (Φ, ρ)-quasi-monotonicityare introduced for functions defined in Banach spaces. Series of necessary conditions are also given that relate (Φ, ρ)-invexity and generalized (Φ, ρ)-invexity of the function with (Φ, ρ)monotonicity and generalized (Φ, ρ)-monotonicity of its gradient.

DNA polymerase eta (Pol eta) functions in the proficient bypass of a variety of DNA lesions. Relative to the replicative polymerases, Pol eta has a greater tolerance for distorted DNA geometries and possesses a low fidelity. X-ray crystal structures and studies with nucleotide analogs have implicated interactions with the DNA minor groove as being crucial for the high fidelity of replicative DN...