Introduction: This work demonstrates the application of in vivo MRS of hyperpolarized [1-C]pyruvate to interrogate a metabolic pathway involved in neither glycolysis nor the Krebs cycle. In particular, ethanol is metabolized in the liver via the breakdown of ethanol to acetaldehyde and acetaldehyde to acetate. These reactions are catalyzed by the enzymes alcohol dehydrogenase (ADH) and acetalde...

In a recent study Drosophila larvae were injected with bacterial lipopolysaccharide (LPS) suspended in 1% ethanol and differentially induced protein fractions were identified. The levels of several proteins, including alcohol dehydrogenase (ADH), increased in LPS-treated flies and were labelled as immune response proteins. However, because control larvae were not injected with ethanol alone the...

BACKGROUND Previous studies have used c-Fos-like immunoreactivity (cFLI) to examine the neuroanatomical location of cells that are activated in response to ethanol administration. However, the use of cFLI alone fails to reveal the phenotypical identity of cells. In the present study we used double-labeling procedures to identify the neurochemical phenotype of neurons that showed ethanol-induced...

Ethanol biofuel could play an important role in reducing petroleum consumption by enabling a substantial increase in the fuel efficiency of gasoline engine vehicles. This ethanol boosted engine concept uses a small amount ethanol to increase the efficiency of use of a much larger amount of gasoline by approximately 30%. Gasoline consumption and the corresponding CO2 emissions would thereby be r...