Hydantoin derivatives, including phenytoin (5,5-diphenylhydantoin), have recently gained attention as they possess a variety of important biochemical and pharmacological properties. Nevertheless, available information on anticancer activity of hydantoin derivatives is still scarce. Here, we evaluated possible antileukemic potential of four phenytoin analogs, namely: methyl 2-(2,4-dioxo-5,5-diph...

Mol-ecules of the title compound, C(11)H(15)NO(2), are essentially planar (r.m.s. deviation = 0.035 Å) and are linked into a chain along the a axis by weak C-H⋯O hydrogen bonds.

The role of neuropeptide Y Y2 receptor (Y2R) in human diseases such as obesity, mood disorders, and alcoholism could be better resolved by the use of small-molecule chemical probes that are substantially different from the currently available Y2R antagonist, N-[(1S)-4-[(aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydr...

In the asymmetric unit of the title compound, C(10)H(11)NO(4), there are two crystallographically independent mol-ecules, which are connected via a C-H⋯O hydrogen bond. The crystal structure is stabilized by this hydrogen bond together with an N-O⋯π contact [O⋯Cg 3.297 (5) Å; Cg is the centroid of one of the benzene rings].

is not favorable (AH = + 3 1.5 kcal). Our conclusion is that an important catalytic site involves two adjacent surface dioxo units (the dual dioxo site), with each dioxo site extracting one H in a sequence of steps. The required dual dioxo site exists on the (010) surface of MOO, but does not exist on the other low index surfaces. This mechanism is supported by atmospheric pressure experimental...

Selective activation of the neuropeptide Y (NPY)2 receptor to suppress appetite provides a promising approach to obesity management. A selective NPY2 polyethylene glycol-conjugated (PEGylated) peptide agonist is described that consists of a peptide core corresponding to residues 13 to 36 of human peptide YY (PYY) and a nonpeptidic moiety (2-mercaptonicotinic acid) at the peptide N terminus that...