We have exploited the "interference" of ethylene glycol in the Du Pont aca triglyceride method to develop a convenient and rapid screening method for detecting ethylene glycol in serum. Pretreatment of patient's serum with lipase, glycerol kinase, and other cofactors usually added for triglyceride analysis removes triglycerides and glycerol, but not ethylene glycol, from the sample. The aca tri...

The interactions of ethylene glycol with a partially reduced rutile TiO2(110) surface have been studied using temperature programmed desorption (TPD). The saturation coverage on surface Ti rows is determined to be 0.43 monolayer (ML), slightly less than one ethylene glycol per two Ti sites. Most of the adsorbed ethylene glycol (∼80%) undergoes further reactions to yield other products. Two majo...

Ethylene glycol (EG) may be consumed accidentally or intentionally, usually in the form of antifreeze products or as an ethanol substitute. EG is metabolized to toxic metabolites. These metabolites cause metabolic acidosis with increased anion gap, renal failure, oxaluria, damage to the central nervous system and cranial nerves, and cardiovascular instability. Early initiation of treatment can ...

We discuss a case of a 17-year-old white male who intentionally ingested a tick and flea insecticide and was admitted to the emergency room unconscious, with signs and symptoms of cholinergic toxicity. Capillary gas chromatography and electron-impact mass fragmentographic analysis of the patient's urine and serum demonstrated the presence of poly-ethylene glycol and propoxur (o-isopropoxyphenyl...

Background: Toxic alcohol poisonings are responsible for high mortality and morbidity in Russia. This study was aimed to evaluate the trends of harmful ethanol (EtOH) drinking as well as methanol (MeOH), isopropanol (IPA) and ethylene glycol (EG) poisonings in the Middle Urals region of Russia. Methods: In this retrospective study, the medical records of patients poisoned with MeOH, IPA and EG ...

A rapid headspace-gas chromatography (HS-GC) method was developed for the analysis of ethylene glycol and propylene glycol in plasma and serum specimens using 1,3-propanediol as the internal standard. The method employed a single-step derivitization using phenylboronic acid, was linear to 200 mg/dL and had a lower limit of quantitation of 1 mg/dL suitable for clinical analyses. The analytical m...