Hypercalcemia is usually caused by malignancies or primary hyperparathyroidism, and only rarely by drugs [1]. Hypercalcemia can occasionally cause acute pancreatitis [2]. We herein report a case of severe acute pancreatitis induced by hypercalcemia which developed as a reaction to ointment containing 22oxacalcitriol, a vitamin D3 analogue. A 72-year-old Japanese man with more than a 50-year his...

M.J. Korstanje, Department of Dermatology, Academic Hospital Maastricht, PO Box 1918, NL–6201 BX Maastricht (The Netherlands) The effectiveness of ciclosporin (CsA) in severe plaque psoriasis is established [1. 2]. However. CsA may not be randomly used in clinical practice because of its side effects, which include hepatotoxicity. acute and chronic nephrotoxicity, hirsutism. hypertension and to...

In general, progress in translating preclinical chemoprevention studies to the clinic has been limited to hormone-responsive tumors (breast, prostate), and to date, has not been widely adopted. Either the toxicities have been too great for general usage despite a definitive positive clinical trial (e.g., 13-cisretinoic acid for suppressing oral leukoplakia or preventing secondary head and neck ...

Ocular involvement of lichen planus (Lp) is a rare event. Only 10 cases with Lp of the eyelids have been reported in the literature. Ocular Lp may also affect mucosal surfaces of the eye and lead to cicatrizing conjunctivitis. Lp of the eyelids may appear as isolated lesions and in those cases diagnosis is very difficult. Lp should be considered in the differential diagnosis of all erythematous...

Malignant gliomas account for more than 60% of all primary brain tumors in adults. Adjuvant chemotherapy in addition to radical surgery and radiation therapy has provided only a modest increase in survival. Retinoic acid has been shown to have growth-inhibitory activity against glioma cells in culture This provides the rationale for a Phase II study using 13-cis-retinoic acid (CRA) in patients ...

Class 2–4 topical glucocorticoids are the treatment of choice for cutaneous lupus erythematosus (CLE). A randomized, controlled study has shown that fluocinonide 0.05 % is more effective than hydrocortisone 1 [1]. 4 indicated lesions on capillitium, palms hands/soles feet, and hyperkeratotic lesions, covered by a foil/hydrocolloid dressing where required. Strictly intralesional injections triam...