نتایج جستجو برای: excision cavity volume ecv
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PURPOSE Myocardial T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in patients with diffuse myocardial fibrosis. The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents. METHODS A modified Look-Locker Inversion Recovery (MOLLI) sequence was acquired at 3 T in 24 healthy subjects (8 men...
BACKGROUND Myocardial fibrosis is a hallmark of hypertrophic cardiomyopathy (HCM) and a potential substrate for arrhythmias and heart failure. Sarcomere mutations seem to induce profibrotic changes before left ventricular hypertrophy (LVH) develops. To further evaluate these processes, we used cardiac magnetic resonance with T1 measurements on a genotyped HCM population to quantify myocardial e...
Background The calculation of the extracellular volume fraction (ECV) requires accurate quantification of myocardial and blood pool T1. Some Modified look locker inversion recovery (MOLLI) sequences provide a T1 and T1* output. T1* does not use a look locker correction, and so it is theoretically a more accurate estimation of true T1 blood T1 because fresh spins are flowing into the imaging pla...
Background The T1-mapping MOLLI technique has already proved to be a robust and reproducible technique for myocardial extracellular volume fraction (ECV) estimation in both healthy individuals and patients with different cardiomyopathies. Monozygotic twins share the same DNA information and frequently grow up in a similar environment. However, epigenetic as well as environmental factors may lea...
OBJECTIVES The goal of this study was to assess the relationship among extracellular volume (ECV), native T1, and systolic strain in hypertensive patients with left ventricular hypertrophy (HTN LVH), hypertensive patients without LVH (HTN non-LVH), and normotensive controls. BACKGROUND Diffuse myocardial fibrosis in HTN LVH patients, as reflected by increased ECV and native T1, may be an unde...
Abstract Funding Acknowledgements Type of funding sources: None. Background Myocardial fibrosis (MF) is a common endpoint in the majority pathological mechanisms affecting cardiac muscle, ultimately resulting failure. Cardiovascular magnetic resonance (CMR) with gadolinium-based contrast agent and T1 mapping technique able to deliver non-invasive quantification extracellular volume (ECV) expans...
Background Measurement of myocardial extracellular volume fraction (ECV) with T1 mapping cardiac magnetic resonance (CMR) before and after the application of a gadolinium-based extracellular contrast agent enables the assessment of diffuse myocardial fibrosis. The equilibrium between blood and myocardium contrast concentration required for ECV measurements can be achieved with a primed contrast...
Background Quantitative myocardial T1 mapping provides in-vivo tissue characterization for assessment of cardiomyopathies. Pre and post-contrast T1 maps can be used to calculate the extracellular volume fraction (ECV) to detect diffuse myocardial fibrosis. Several imaging approaches have recently been proposed for measuring T1 values [1-4], but no head-to-head comparison has been reported to cr...
BACKGROUND Cardiac impairment is associated with high morbidity and mortality in immunoglobulin light chain (AL) type amyloidosis, for which early identification and risk stratification is vital. For myocardial tissue characterization, late gadolinium enhancement (LGE) is a classic and most commonly performed cardiovascular magnetic resonance (CMR) parameter. T1 mapping with native T1 and extra...
Background Hypertrophic cardiomyopathy (HCM) is associated with significant associated morbidity and mortality. Increased maximal left ventricular wall thickness (LVWT) has been postulated as major risk factor of sudden death; however, relatives with normal LVWT are also at risk. Genetically driven interstitial collagenesis has been proposed as a possible mechanism of diffuse myocardial fibrosi...
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