Although it is currently understood that the exon junction complex (EJC) is recruited on spliced mRNA by a specific interaction between its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts of not only intron-containing but also intronless genes on Drosophila polytene chromosomes. Additionally, ...

In (EJC 11 (2004), #R84), Remmel and Wachs presented two natural ways to define p, qanalogues of the generalized Stirling numbers of the first and second kind, S(α, β, r) and S(α, β, r) as introduced by Hsu and Shiue (Adv. App. Math 20 (1998), 366-384). In this paper, we present a rook theoretic model for each type of p, q-analogue based on a pair of boards parametrized by the nonnegative integ...

Kaposi's sarcoma-associated herpesvirus (KSHV) expresses numerous intronless mRNAs that are unable to access splicing-dependent cellular mRNA nuclear export pathways. To circumvent this problem, KSHV encodes the open reading frame 57 (ORF57) protein, which orchestrates the formation of an export-competent virus ribonucleoprotein particle comprising the nuclear export complex hTREX, but not the ...

abstract background von willebrand disease (vwd) is an autosomally inherited bleeding disorder with the prevalence of 1% based on population studies. the disease phenotype is due to quantitative and structural/functional defects in von willebrand factor (vwf) which is a glycoprotein with essential role as a carrier of fviii in circulation and also it serves the function as hemostasis regulator....

Exon 2 5'-ACTGCAGGGAGTGAACTGCT-3' 5'-TTATTTTGCGTTTGGTGCAG-3' Exon 3 5'-CGATGATTCAAACCCAGCTT-3' 5'-CCTGCTTCTTCTGATCCTGC-3' Exon 4 Part I 5'-AGAAAGCCACCTCCACAACA-3' 5'-CAGATCTTGAGCCCCTCATC-3' Exon 4 Part II 5'-TGGCCAGCCAGATCTTGC-3' 5'-GCAGCCCAACTCTGCTTTAT-3' Exon 5 5'-TGGGGCTTGTACTCATTCTT-3' 5'-CTGGTTTTCTGATGGACAGC-3' Exon 6 5'-CCCTGACCCTACAACT-3' 5'-AGAGGGGTTCCCTTAC-3' Exon 7 Part I 5'-ACACATTTT...

background: ataxia with oculomotor apraxia type 1 (aoa1) shows early onset with autosomal recessive inheritance and is caused by a mutation in the aprataxin (aptx) gene encoding for the aptx protein. methods: in this study, a 7-year-old girl born of a first-cousin consanguineous marriage was described with early-onset progressive ataxia and aoa, with increased cholesterol concentration and decr...

objective(s) deregulation of the immune system through allied factors and cytokine responses are thought to be important contributors to the pathogenesis of asthma. vitamin d3 and its nuclear receptor appear to be factors that maybe involved in regulating immune responses during the progression of asthma. the aim of this study was to investigate the association between polymorphisms in intron 8...