نتایج جستجو برای: exosome activity

تعداد نتایج: 1137073  

Journal: :PLoS ONE 2007
Hiroaki Murakami Derek B. Goto Takashi Toda Ee Sin Chen Shiv I. Grewal Robert A. Martienssen Mitsuhiro Yanagida

BACKGROUND Cellular RNA metabolism has a broad range of functional aspects in cell growth and division, but its role in chromosome segregation during mitosis is only poorly understood. The Dis3 ribonuclease is a key component of the RNA-processing exosome complex. Previous isolation of the dis3-54 cold-sensitive mutant of fission yeast Schizosaccharomyces pombe suggested that Dis3 is also requi...

2013
Alberto Benito-Martin Alvaro Conrado Ucero Irene Zubiri Maria Posada-Ayala Beatriz Fernandez-Fernandez Pablo Cannata-Ortiz Maria Dolores Sanchez-Nino Marta Ruiz-Ortega Jesus Egido Gloria Alvarez-Llamas Alberto Ortiz

Urinary exosomes have been proposed as potential diagnostic tools. TNF superfamily cytokines and receptors may be present in exosomes and are expressed by proximal tubular cells. We have now studied the expression of selected TNF superfamily proteins in exosome-like vesicles from cultured human proximal tubular cells and human urine and have identified additional proteins in these vesicles by L...

2009
Nowel Azzouz Olesya O. Panasenko Geoffroy Colau Martine A. Collart

BACKGROUND Ccr4-Not is a highly conserved multi-protein complex consisting in yeast of 9 subunits, including Not5 and the major yeast deadenylase Ccr4. It has been connected functionally in the nucleus to transcription by RNA polymerase II and in the cytoplasm to mRNA degradation. However, there has been no evidence so far that this complex is important for RNA degradation in the nucleus. MET...

Journal: :Advances in experimental medicine and biology 2010
Phil Mitchell David Tollervey

We describe the events surrounding the identification of the exosome complex and the subsequent early development of the field. Like many scientific discoveries, the initial identification and characterization ofthe exosome was based on a combination of skill, good fortune--and the availability of cutting edge technology.

Journal: :Cell 2015
Jillian S. Losh Ambro van Hoof

The RNA exosome degrades many different RNAs. Thoms et al. now fill an important gap in our understanding of how the exosome recognizes distinct subsets of target RNAs.

2018
Elie Beit-Yannai Saray Tabak W Daniel Stamer

Exosomes are extracellular nanovesicles that mediate a number of cellular processes, including intracellular signalling. There are many published examples of exosome-exosome dimers; however, their relevance has not been explored. Here, we propose that cells release exosomes to physically interact with incoming exosomes, forming dimers that we hypothesize attenuate incoming exosome-mediated sign...

2014
Heike Lange Hélène Zuber François M. Sement Johana Chicher Lauriane Kuhn Philippe Hammann Véronique Brunaud Caroline Bérard Nathalie Bouteiller Sandrine Balzergue Sébastien Aubourg Marie-Laure Martin-Magniette Hervé Vaucheret Dominique Gagliardi

The RNA exosome is the major 3'-5' RNA degradation machine of eukaryotic cells and participates in processing, surveillance and turnover of both nuclear and cytoplasmic RNA. In both yeast and human, all nuclear functions of the exosome require the RNA helicase MTR4. We show that the Arabidopsis core exosome can associate with two related RNA helicases, AtMTR4 and HEN2. Reciprocal co-immunopreci...

2015
Guoxin Liang Guangyan Liu Kouichi Kitamura Zhe Wang Sajeda Chowdhury Ahasan Md Monjurul Kousho Wakae Miki Koura Miyuki Shimadu Kazuo Kinoshita Masamichi Muramatsu

Transforming growth factor (TGF)-β inhibits hepatitis B virus (HBV) replication although the intracellular effectors involved are not determined. Here, we report that reduction of HBV transcripts by TGF-β is dependent on AID expression, which significantly decreases both HBV transcripts and viral DNA, resulting in inhibition of viral replication. Immunoprecipitation reveals that AID physically ...

2018
Yujie Ning Xi Wang Pan Zhang Amin Liu Xin Qi Meidan Liu Xiong Guo

Previous studies have identified a close association between diet and the prevalence of Kashin-Beck disease (KBD); however, the mechanisms via which the diet protects against KBD-associated cartilage injury has remained elusive. Recent international research studies have revealed a therapeutic role of dietary exosome micro (mi)RNAs in repairing chondrocyte lesions by regulating genes and protei...

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