Targeted T cells are emerging as effective non-toxic therapies for cancer. Multiple elements, however, contribute to the overall pathogenesis of cancer through both distinct and redundant mechanisms. Hence, targeting multiple cancer-specific markers simultaneously could result in better therapeutic efficacy. We created a functional chimeric antigen receptor-the TanCAR, a novel artificial molecu...

Animal models of neurodegenerative and inflammatory diseases, have greatly contributed to our understanding of human disorders such as multiple sclerosis (MS). These models play a key role in drug development and have led to novel therapeutic approaches to treat human diseases. Nevertheless, some studies showing efficacy of therapies in animal models have not translated well to the clinic. In p...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...

Pulmonary hypertension (PH) is a multifactorial disease, commonly associated with heart failure. Different experimental models have emerged to help in the understanding of the molecular and cellular mechanisms associated with human PH, providing also a useful approach to test experimental therapies for PH treatment. Although there is no ideal animal model that mimics human PH, animal models hav...

The fundamental purpose of this article is to review the human’s bosom buddy beagle dog as a pet animal, an experimental animal model for basic research methodology, and other uses breed in various field. Main focus paper light up anatomical physiological resemblance humans with brief idea about disease pathology treatment. collect different diseases that associated eyes, oral system, CVS bone ...