1Department of Basic Sciences, University of Social Welfare and Rehabilitation Sciences, Tehran, IR Iran 2Department of Medical Basic Sciences, Faculty of Allied Medicine, Iran University of Medical Sciences, Tehran, IR Iran 3Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, IR Iran 4Multiple Sclerosis Research Center, Neuroscience Institute, Sina Hospital, Te...

The activity of acid sphingomyelinase (aSMase) was previously reported to be involved in glucocorticoid-induced cell death (GICD) of T lymphocytes. This mechanism in turn is believed to contribute to the therapeutic efficacy of glucocorticoids (GCs) in the treatment of inflammatory diseases. In this study, we reassessed the role of aSMase in GICD by using aSMase knockout mice. The absence of aS...

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...

A major disease-inducing site for induction of experimental allergic encephalomyelitis in monkeys exists in Peptide P 14, the 37-residue segment of the A1 protein comprising its COOH-terminus. The peptide appears to contain the dominant encephalitogenic determinant, since it was as active as the A1 protein on a molar basis. By contrast, the 9-residue tryptophan region and the Peptide R region, ...

[This corrects the article DOI: 10.1371/journal.pone.0110048.].

Approved: ____________________________________ Thesis Supervisor ____________________________________ Title and Department ____________________________________ Date 1 THE ANTI-INFLAMMATORY RESPONSE IN MICE WITH CORONAVIRUSINDUCED ENCEPHALOMYELITIS by Kathryn Rydze Trandem A thesis submitted in partial fulfillment of the requirements for the Doctor of Philosophy degree in Immunology in the Gradu...