Randomised controlled trials (RCTs) must be internally valid (i.e., design and conduct must eliminate the possibility of bias), but to be clinically useful, the resultmust also be relevant to a definable group of patients in a particular clinical setting (i.e., they must be externally valid). Lack of external validity is the most frequent criticism by clinicians of RCTs, systematic reviews, and...

OBJECTIVES To identify and quantify determinants of captan exposure among 74 private orchard pesticide applicators in the Agricultural Health Study (AHS). To adjust an algorithm used for estimating pesticide exposure intensity in the AHS based on these determinants and to compare the correlation of the adjusted and unadjusted algorithms with urinary captan metabolite levels. METHODS External ...

The specific aim of this academic study is to investigate the possible impacts of external and internal factors in the unique process of privatization on the changes of management accounting practices in listed companies of Tehran Stock Exchange which more than 51% of this companies' shares have been transferred to the private sector. For this purpose, a theoretical framework scientifically bas...

The relatively high level of Nigeria’s external indebtedness, and rising debt burden which has serious implications on the country’s development and debt sustainability in terms of ability to pay has led to continued deterioration in Nigeria’s economic performance. This study examines the extent to which Nigeria’s external debt relates to indices of ability to pay in order to ascertain the sust...

The origins of cortical interneurons in rodents have been localized to the embryonic subcortical telencephalon where distinct neuroepithelial precursors generate defined interneuron subsets. A swathe of research activity aimed at identifying molecular determinants of subtype identity has uncovered a number of transcription factors that function at different stages of interneuron development. Pa...

This study aims at contributing to a better understanding of business-to-business Electronic Commerce (EC) advantages and determinants of these advantages. A research model was empirically tested on a sample of 143 Canadian companies. Key findings indicate that the most important advantages of EC are increased productivity, increased quality of products and services, competitive advantage, and ...

The creative design process is often characterised by high task uncertainty and tight dependency on other functions both within a firm and with external parties. Coordination thus plays a key role in integrating different functions related to the design process in attaining a common objective of delivering products to end customers. This paper examines coordination mechanisms and their determin...

An increasingly large number of firms outsource their Information Technology (IT). Firms that contemplate IT outsourcing have two alternatives: (1) contract with a vendor (i.e., outsourcing) or (2) set up their own IT subsidiary (i.e. quasi-outsourcing). This study examines some of the determinants of the outsourcing vs. quasi-outsourcing decision. Using primary data collected in France and Ger...

Global population aging over recent years has been linked to poorer health outcomes and higher healthcare expenditure. Policies focusing on healthy aging are currently being developed but a complete understanding of health determinants is needed to guide these efforts. The built environment and other external factors have been added to the International Classification of Functioning as importan...