The hydrostatic extrusion is a new method of extrusion process. The most important advantage of this method is reduction of friction and close tolerance for the coating thickness. In this study, the hydrostatic extrusion simulation of bimetallic wires has performed using of finite element method. In the following the advantages of hydrostatic extrusion compared to the direct extrusion are prese...

This paper reports the influence of post-melt impeller speed, post-melt processing time, binder concentration and particle size of bulk material on the sphericity of pellets produced by melt pelletization in a high shear mixer. Lactose was used as the bulk material with polyethylene glycol 3000 as a meltable binder. The sphericity of pellets was found to be affected by post-melt impeller speed ...

BACKGROUND Different methods have been studied for targeting drugs to the colon, such as pH-based, time dependent and bacterially degradable systems. However, due to variations in physiological conditions of patients, one system alone could not be completely reliable on colonic drug delivery. OBJECTIVES The aim of this study was preparation and evaluation of a novel colon-specific drug delive...

Department of Pharmaceutics, Department of Phytopharmacy and Pharmacognosy, JSS College of Pharmacy, Udhagamandalam-643001, Tamil Nadu, India Abstract The objective of present work was to prepare a dual release drug delivery systems comprising fast and delayed release pattern using solid dispersion and pellets of the aceclofenac to achieve a desired in vitro and in vivo profile. Aceclofenac sol...

BACKGROUND Amoxicillin is a commonly used antibiotic which has a short half-life in human. The frequent administration of amoxicillin is often required to keep the plasma drug level in an effective range. The short dosing interval of amoxicillin could also cause some side effects and drug resistance, and impair its therapeutic efficacy and patients' compliance. Therefore, a three-pulse release ...

Aluminum matrix composites reinforced with Al2O3 and SiC particles (5 Vol%) were produced using the hot powder extrusion method. Extrusion temperature and extrusion reduction in area were chosen in the range of 500 to 600°C and 90 to 95%, respectively. The physical and mechanical properties of the extruded composites such as density, tensile strength, elongation and microhardness were evaluated...

Aluminum matrix composites reinforced with Al2O3 and SiC particles (5 Vol%) were produced using the hot powder extrusion method. Extrusion temperature and extrusion reduction in area were chosen in the range of 500 to 600°C and 90 to 95%, respectively. The physical and mechanical properties of the extruded composites such as density, tensile strength, elongation and microhardness were evaluated...

The hydrostatic extrusion is a new method of extrusion process. The most important advantage of this method is reduction of friction and close tolerance for the coating thickness. In this study, the hydrostatic extrusion simulation of bimetallic wires has performed using of finite element method. In the following the advantages of hydrostatic extrusion compared to the direct extrusion are prese...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...