Streptomyces are the most popular among Actinomycetes groups and found in soils worldwide. They form an important part of soil ecology within Actinomycetales order. diverse as secondary antibiotic metabolites such Novobiocin, Amphotericin, Vancomycin, Neomycin, Gentamicin, Chloramphenicol, Tetracycline, Erythromycin Nystatin. Thus, current study was aimed to isolate, identify assess active prod...

Introduction: Drug abuse is a public health problem around the globe. Its implications in human are harmful, compromising nutritional status. It has been shown that malnutrition moderately prevalent drug addicts, and prescription significantly beneficial for these patients. Available literature suggests altered blood serum biochemical data addicts. Our study focused on biomarkers addicts who di...

Abstract Study objective: The activity of linsitinib, a small molecule inhibitor the insulin-like growth factor 1 receptor (IGF-1R), was assessed in mouse model Graves’ orbitopathy (GO). GO is most common extra-thyroidal manifestation disease (GD), which caused by autoantibodies against thyroid stimulating hormone (TSHR). Methods: GD induced mice immunization with human TSHR A-subunit encoding ...

INTRODUCTION Food supplemented with probiotic bacteria is a rapidly growing sector of the market. The aim of the present study was to evaluate and compare the acid production of selected probiotic strains available in commercial products. METHODS Six Lactobacillus strains (Lactobacillus plantarum 299v and 931; Lactobacillus rhamnosus GG and LB21; Lactobacillus paracasei subsp. paracasei F19, ...

Disturbances in intestinal microbial ecology and in the immune system of the host have been implicated as a part of the pathogenesis in chronic fatigue syndrome. Probiotic lactic acid producing bacteria have been shown to prevent and alleviate gastrointestinal disturbances and to normalize the cytokine profile which might be of an advantage for patients suffering from chronic fatigue syndrome. ...

Sodium caseinates prepared from bovine, sheep, goat, pig, buffalo or human milk were hydrolyzed by a partially purified proteinase of Lactobacillus helveticus PR4. Peptides in each hydrolysate were fractionated by reversed-phase fast-protein liquid chromatography. The fractions which showed the highest angiotensin I-converting-enzyme (ACE)-inhibitory or antibacterial activity were sequenced by ...

This study was conducted to test the hypothesis that, during renal development, the Na-K-2Cl cotransporter type 2 (NKCC2) activates the tonicity-responsive enhancer binding protein (TonEBP) transcription factor by creating medullary hypertonicity. TonEBP, in turn, drives the expression of aldose reductase (AR) and urea transporter-A (UT-A). Kidneys from 13- to19-day-old fetuses (F13-F19), 1- to...

The UK government has recently recognised the need to improve mental health services in the country. Electronic health records provide a rich source of patient data which could help policymakers to better understand needs of the service users. The main objective of this study is to unveil statistics of diagnoses recorded in the Case Register of the South London and Maudsley NHS Foundation Trust...