نتایج جستجو برای: f2 isoprostanes
تعداد نتایج: 13659 فیلتر نتایج به سال:
Introduction Cancer has been associated with increased oxidative stress and deregulation of bioactive oxylipins derived from long-chain polyunsaturated fatty acids (LC-PUFA) like arachidonic acid (AA). There is a debate whether ω-3 LC-PUFA could promote or prevent prostate tumor growth through immune modulation reduction stress. Our aim was to study the association between enzymatically non-enz...
Unlike F4-neuroprostanes (F4-NeuroPs), which are relatively selective in vivo markers of oxidative damage to neuronal membranes, there currently is no method to assess the extent of free radical damage to myelin with relative selectively. The polyunsaturated fatty acid adrenic acid (AdA) is susceptible to free radical attack and, at least in primates, is concentrated in myelin within white matt...
F2-Isoprostanes (IsoPs) are isomers of prostaglandin F2a formed from the nonenzymatic free radicalcatalyzed peroxidation of arachidonic acid. Since discovery of these molecules by Morrow and Roberts in 1990, F2-IsoPs have been shown to be excellent biomarkers as well as potent mediators of oxidative stress in vivo in humans. Isofurans (IsoFs) are also oxidation products generated from the nonen...
In vitro and animal studies suggest that oxidative stress is associated with endothelial dysfunction. We tested whether local oxidative stress and nitric oxide (NO) bioavailability in the coronary circulation is associated with coronary endothelial dysfunction in humans. Blood samples were obtained simultaneously from the left main coronary artery and the coronary sinus for measurement of F2-is...
In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Keaney and colleagues1 report that smoking, diabetes, and obesity are independently associated with increased oxidative stress in men and women in a large community-based cohort. While a number of investigators have examined the association between risk factors for cardiovascular diseases (CVDs) and markers of oxidative stress...
Oxidative damage and inflammation are both implicated in the genesis of hypertension; however, the mechanisms by which these stimuli promote hypertension are not fully understood. Here, we have described a pathway in which hypertensive stimuli promote dendritic cell (DC) activation of T cells, ultimately leading to hypertension. Using multiple murine models of hypertension, we determined that p...
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