OBJECTIVES To study the familial aggregation of rheumatoid arthritis (RA) in The Netherlands and to analyse the effect of proband characteristics on the concordance rates for RA. Secondary aims were to compare the characteristics of patients in an early RA inception cohort with those of regular patients and to select Dutch families for the genome-wide scan carried out by the European Consortium...

Granulomatous inflammatory diseases are disorders of an undetermined etiology, affecting different organs and having a diverse clinical course. Familial aggregation of these disorders is being reported increasingly, most commonly familial Crohn's disease. We described the coexistence of Crohn's disease and necrotizing sarcoid-like granulomatous disease in two siblings from a first-degree consan...

Though the familial occurrence of virilization associated with hyperplasia of the adrenal cortex has long been established, there have been only two reports of the familial aggregation of virilizing adrenal carcinoma. It is the purpose of the present communication to describe a family in which 2 sibs, who were products of a consanguineous marriage, had virilizing tumours ofthe adrenal cortex pr...