Background: A higher frequency of skewed X chromosome inactivation has been reported in a consecutive series of young patients with breast cancer compared with controls of a similar age. Objective: To investigate the X inactivation pattern in patients with familial non-BRCA1/BRCA2 breast cancer (n = 272), BRCA1/BRCA2 germline mutations (n = 35), and sporadic breast cancer (n = 292). Methods: X ...

BACKGROUND Studies from Europe and North America suggest that 20 - 50% of patients with dilated cardiomyopathy (DCM) may have familial disease. There is little information on the frequency and clinical genetics of familial DCM in Africa. PURPOSE To determine the frequency and probable mode of inheritance of familial DCM in patients referred for investigation of the cause of DCM at a tertiary ...

Purpose: We studied the inheritance pattern, clinical features and outcome in children with vesicoureteral reflux (VUR). Characteristics of known familial VUR cases were also compared with those of sporadic VUR. Material and Methods: 726 patients were treated for VUR between 19902004. The families were contacted by letter inquiring if other members of the family were affected. The phenotype of ...

INTRODUCTION The histological and immunohistochemical profile of medullary thyroid carcinoma is ill-defined. The objective of this study was to determine the epidemiological, histological, and immunohistochemical characteristics of medullary carcinoma and to analyze whether differences exist between sporadic and familial carcinomas. PATIENTS AND METHODS Fifty-five histologically confirmed tum...

Crime forecasting is notoriously difficult. A crime incident is a multi-dimensional complex phenomenon that is closely associated with temporal, spatial, societal, and ecological factors. In an attempt to utilize all these factors in crime pattern formulation, we propose a new feature construction and feature selection framework for crime forecasting. A new concept of multi-dimensional feature ...

Familial cerebral aneurysms are currently the subject of burgeoning interest. We review the pertinent, recent reports on this topic in the light of our study of 17 families with familial cerebral aneurysms. The prevalence of familial cerebral aneurysms ranges from 5-28%. The sex distribution displays a female bias. Mothers are more often affected than fathers and daughters more than sons. There...