Signal transduction pathways regulate the production and function of many cytokines implicated in immune-mediated diseases. Targeting these enzymes with small molecule inhibitors represents a fertile field for the treatment of rheumatoid arthritis. Recent successes with compounds that block upstream kinases suggest that proximal members of the signaling cascades, such as Rac and other Rho famil...

Payloads transported over a Softwire mesh service (as defined by BGP Encapsulation Subsequent Address Family Identifier (SAFI) information exchange) often carry a number of identifiable, distinct flows. It can, in some circumstances, be desirable to distribute these flows over the equal cost multiple paths (ECMPs) that exist in the packet switched network. Currently, the payload of a packet ent...

The Spatial Interaction Model proposed by Alonso as “Theory of Movements” offers a new specification of spatial origin-destination flow models. Equations for flows between regions, total outflow from and total inflow to a region are linked by balancing factors. The paper presents a consistent formulation of Spatial Interaction Models in the Wilson tradition and Alonso’s General Theory of Moveme...

Time and space assembly line balancing considers realistic multiobjective versions of the classical assembly line balancing industrial problems, involving the joint optimisation of conflicting criteria such as the cycle time, the number of stations, and/or the area of these stations. The aim of this contribution is to present a new algorithm, based on the GRASP methodology, for the 1/3 variant ...

This paper presents a scalability and load balancing study of the All-Path protocols, a family of distributed switching protocols based on path exploration. ARP-Path is the main protocol and it explores every possible path reaching from source to destination by using ARP messages, selecting the lowest latency path. Flow-Path and Bridge-Path are respectively the flow-based and bridge-based versi...

Malay women today have experienced major changes in their careers. However, unlike men, they are still bound by the responsibility of managing households, even though Balancing between careers and households is difficult, face various challenges, which been highlighted authors, most prominent one being Zurinah Hassan. Hassan’s short stories that discuss these issues scarcely studied, leaving a ...

determination of shipment quantity and distribution problem is an important subject in today’s business. this paper describes the inventory/distribution network design. the system addresses a class of distribution network design problem, which is characterized by multiple products family, multiple warehouses and retail-ers. the maximum capacity of vehicles and warehouses are also known. the res...

Preimplantation genetic diagnosis (PGD) is a reproductive technology used with an in vitro fertilization (IVF) cycle to increase the potential for a successful pregnancy and delivery. The most common applications for PGD include testing for extra or missing chromosomes (aneuploidy screening), familial structural chromosome rearrangements, and diagnosis of genetic disease in couples of increased...

Returning genetic research results to relatives raises complex issues. In order to inform the U.S. debate, this paper analyzes international law and policies governing the sharing of genetic research results with relatives and identifies key themes and lessons. The laws and policies from other countries demonstrate a range of approaches to balancing individual privacy and autonomy with family a...