Objective: Stroke is associated with high risks for mortality. The bidirectional communication between ischemic brain and other organ dysfunctions widely recognized. However, the mechanisms underlying cerebrorenal crosstalk remains unclear. Herein, we investigated effect of stroke on kidney using a middle cerebral artery occlusion (MCAO) model. Moreover, explored effects overexpression liver-ty...

Interactions of fatty acids with the potassium channel KcsA were studied using Trp fluorescence quenching and electron paramagnetic resonance (EPR) techniques. The brominated analogue of oleic acid was shown to bind to annular sites on KcsA and to the nonannular sites at each protein-protein interface in the homotetrameric structure with binding constants relative to dioleoylphosphatidylcholine...

boraginaceae family is known as a medicinal plant classified in dicotyledons.  it is originated from asia (middle east). the aim of this study was to evaluate ingredient between 4 species of boraginaceae family based on physiological & phytochemical traits as well as seed fatty acid contents.  4 species (e. russicum, e. italicum, e. amoenum, and b. officinalis ) were evaluated carefully. all se...

The mechanism by which fatty acids transverse the plasma membrane has been a controversial subject. Kinetic studies of fatty acid uptake suggested the presence of a protein carrier system in certain cells which exhibit rapid fatty acid influx and/or efflux such as hepatocytes, adipocytes and jejunal mucosal cells. Five plasma membrane proteins have been identified and proposed as candidates for...

Fatty acid-binding protein (FABP) from rat liver cytosol is an abundant 14 000-M, monomeric protein that is known to have a high affinity for both fatty acids and their CoA esters, as well as a number of non-polar organic anions (Glatz & Veerkamp, 1985). The precise physiological role of this protein remains unclear and clarification of its functions will require more precise information on its...

Two abundant fatty acid-binding proteins (MFB1 and MFB2) were isolated from the midgut cytosol of larval Manduca sexta. As isolated, MFB1 and MFB2 were found to contain bound fatty acids in a 1:1 molar stoichiometric ratio. Immunological screening demonstrated that MFB1 and MFB2 were restricted to the midgut in a gradient distribution, with MFB1 more concentrated in the anterior two-thirds of t...