the aim of the present study was to develop and investigate the feasibility of delivering nebivolol as a transdermal patch by iontophoresis. the passive and electrically assisted transdermal delivery of nebivolol hydrochloride by iontophoresis will improve the therapeutic efficacy and overcome the difficulties raised in oral drug delivery. because of its extensive hepatic metabolism and low dos...

background: the purpose of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in frozen-thawed embryo transfer (fet) cycles, including that is, oral estradiol and 17ß-estradiol transdermal patch. methods: in this randomized controlled trial, women underwent either conventional ivf or intracytoplasm...

Attention-deficit hyperactivity disorder (ADHD) is characterized by inattention, hyperactivity, and impulsivity. Globally, ADHD affects approximately 5–10% of children and persists into adolescence in up to 85% of affected individuals. Psychostimulants, such as methylphenidate and amfetamine, are the mainstay of treatment in ADHD. A patch that delivers methylphenidate transdermally (methylpheni...

Objective: To formulate economic transdermal patch of lornoxicam (LX) and to study its anti-inflammatory activity on acute and chronic inflammatory in rat models Method: Three LX transdermal patches (F1, F2 and F3) consist of Eudragit RL-100 and RS-100 in three different ratios (1:2, 1:1 and 2:1) were prepared respectively by the solvent evaporation technique. All formulations contain diethylph...

A transdermal patch is a medicated adhesive that applied to the skin contains medication intended be absorbed into bloodstream. This frequently encourages healing of body part has been hurt. Transdermal delivery allows for regulated drug release patient, resulting in less systemic side effects and, certain cases, increased efficacy over other dose forms. an advantage types such as oral, topical...

BACKGROUND To evaluate the efficacy and tolerability of a clonidine transdermal patch in the treatment of children with tic disorders (TD) and to establish a predictive model for patients. METHODS Forty-one patients who met the inclusion criteria entered into 12 weeks of prospective, open, single-group, self-controlled treatment with a clonidine transdermal patch. The Yale Global Tic Severity...

AIM To uptake and release hydrophilic model drugs and insulin in a novel conductive polymer (CP) nanotube transdermal patch. MATERIALS & METHODS The externally controlled transdermal delivery of model drugs and insulin were tested ex vivo and results were compared with CP films. The unique intrinsic properties of CPs provide electrostatic interaction between the model drugs and polymer backbo...

Etosom merupakan suatu sistem pembawa berupa vesikel yang lunak dan elastis dengan komponen utama yaitu fosfopilid, etanol konsentrasi cukup tinggi (20-45%), air. memiliki kemampuan dalam meningkatkan penetrasi obat lebih jauh ke kulit dikarenakan adanya kandungan fosfolipid etanol. juga dapat menghantarkan hingga mencapai sirkulasi sistemik sehingga sangat cocok digunakan sebagai diformulasika...

The cost of treatments for tobacco dependence frequently presents a financial barrier to their use. To overcome such barriers, the Wisconsin Women's Health Foundation, the Wisconsin Bureau of Public Health, the McNeil Consumer Healthcare, and the University of Wisconsin Center for Tobacco Research and Intervention collaborated in an initiative to distribute nicotine patches to Wisconsin women a...