introduction: hemodialysis patients often develop resistance to recombinant human erythropoietin due to functional iron deficiency. in these patients iron therapy can be hazardous leading to hemosiderosis. recent studies have suggested that intravenous ascorbic acid may be able to improve this hyporeponsiveness. the aim of this study was to evaluate the effect of intravenous ascorbic acid on fu...

BACKGROUND The aim of this study was to investigate the relationship between changes in serum ferritin concentrations and the development of metabolic syndrome (MetS) and its components over a 6.5 year follow-up period in Finnish adults. METHODS Adults born in Pieksämäki, Finland, in 1942, 1947, 1952, 1957, and 1962 (n = 1294) were invited to health checkups between 1997 and 1998 and 2003 and...

BACKGROUND Hepcidin is a central regulator of iron homeostasis. Increased hepcidin concentrations could cause iron-restricted erythropoiesis in chronic kidney disease (CKD)-associated anemia. This cross-sectional observational study was conducted to evaluate the association between hepcidin and CKD-associated anemia in non-dialysis CKD patients. METHODS A total of 505 non-dialysis CKD patient...

CONTEXT It has been suggested that elevated serum ferritin is associated with several metabolic disorders. However, there is no reported study assessing any association between serum ferritin and sarcopenia despite the close relationship between sarcopenia and metabolic disorders. OBJECTIVE We investigated whether serum ferritin was associated with sarcopenia in older Koreans. DESIGN AND SE...

Serum ferritin, liver iron stores, and liver histology were studied in 38 children with thalassaemia major who were being treated by regular blood transfusions. There was no correlation between serum ferritin levels and either the number of transfusions or the amount of iron deposited in the liver. However, for a given level of iron stores, ferritin levels were higher in patients with chronic h...

CONTEXT T2* magnetic resonance imaging (MRI) is being increasingly used for the assessment of organ iron content in thalassemics, but cost is a major prohibitive factor for repeated measurements. If serum ferritin correlates well with the T2* MRI liver and heart, it will be economical and more simple tool to assess organ iron deposition. AIMS The aim of this study was to find out the relation...

some recent studies have revealed the relationship among excess ferritin, coronary heart disease, and insulin resistance. to assess the association between serum ferritin concentration and impaired fasting glucose, this study was designed. a total of 187 people including 91 impaired fasting glucose (ifg) subjects and 96 normal glucose subjects who had been recognized in a large epidemiological ...

background obese children are at the risk of micronutrient deficiency especially iron deficiency. given the importance of iron deficiency in this age group and considering the existing discrepancies, present study was performed with the aim of evaluating iron deficiency in obese children. material and method this study was conducted, in the form of a case-control study, on 100 children aged bet...

This paper reports the cosegregation in a three generation pedigree of dominantly inherited cataract with an abnormally high level of serum ferritin. In this family, circulating L ferritin was raised in all subjects affected by cataract independently of iron overload. We suggest that a disorder of ferritin metabolism could be a new genetic disorder leading to lens opacity. Cataracthyperferritae...

objective: preeclampsia is one of the most important complications of pregnancy that is associated with increased morbidity and mortality. the aim of this study was to investigate the relation between serum iron status and ferritin with pre-eclampsia. materials and methods: this case control study evaluated 33 preeclamptic patients and 33 normal pregnant women before parturition in imam hossein...