نتایج جستجو برای: fetal hemoglobin
تعداد نتایج: 142433 فیلتر نتایج به سال:
BACKGROUND Human induced pluripotent stem cells offer perspectives for cell therapy and research models for diseases. We applied this approach to the normal and pathological erythroid differentiation model by establishing induced pluripotent stem cells from normal and homozygous sickle cell disease donors. DESIGN AND METHODS We addressed the question as to whether these cells can reach comple...
The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a validated strategy to improve symptoms and complications of this disease. The development of targeted therapies has been limited by the absence of discrete druggable targets. We developed a unique bead-based strategy for the ident...
I N A RECENT REPORT Lie-Injo and 1 described a condition char.. acterized by a deficiency of both types I and 112 (also designated B and C) of carbonic anhydrase. This deficiency, though associated with a high level of fetal hemoglobin, was not due to hemoglobinopathy, hereditary persistence of fetal hemoglobin, or any of the known types of thalassemia. Because of lack of proof of hereditary ba...
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