Injection drug users uninfected by hepatitis C virus (HCV) despite likely repeated exposure through high-risk behaviour are well documented. Factors preventing infection in these individuals are incompletely understood. Here, we looked for anti-HCV-envelope antibody responses in a cohort of repeatedly exposed but uninfected subjects. Forty-two hepatitis C diagnostic antibody- and RNA-negative i...

The polysaccharide capsule is a major virulence mechanism of Streptococcus pneumoniae, shielding the bacterium from phagocytes. Capsule types may differ in their abilities to resist immune defense. Antibody-mediated complement activation and opsonophagocytosis are crucial in protection against pneumococcus. Conjugate vaccine trials suggest imperfect protection against 19F. We have previously sh...

This paper describes a text-reading tool that makes extensive use of widelyavailable NLP tools and resources to aid non-native English speakers overcome language related hindrances while reading a text. It is a web-based tool, that can be accessed from browsers running on PCs or tablets, and provides the reader with an intelligent e-book functionality.

Material strategy is an important approach to resist the foreign body response (FBR) that commonly associated with implants. Only a handful of promising anti-FBR materials have been reported such as zwitterionic materials, modified alginate, and most recently, poly-β-homoserine. In article number 2007226, Runhui Liu co-workers discuss can prevent implants from recognition by immune cells divers...

CONTEXT Policymaking is a highly complex process that is often difficult to predict or influence. Most of the scholarship examining the role of research evidence in policymaking has focused narrowly on characteristics of the evidence and the interactions between scientists and government officials. The real-life context in which policymakers are situated and make decisions also is crucial to th...