Dermatofibrosarcoma protuberans is a rare low-grade fibrohistiocytic tumor with onset normally at ages between 20 and 50 years. It presents as a violaceous plaque or macule with an appearance suggestive of vascular lesion, on which nodular lesions appear later. Histological diagnosis is based on the presence of a spindle-cell tumor arranged in small bundles in a characteristic cartwheel pattern...

Dermatofibrosarcoma protuberance (DFSP) is a low grade spindle cell malignant tumour that is locally aggressive especially it incompletely excised. A 64-year-old man presented with intra-oral buccal mass of 34 year duration with accelerated increase in size in the last two years. CT scan showed well-circumscribed tumour with no relation to the overlying skin. Fine needle aspiration cytology rev...

dermatofibrosarcoma protuberans (DFSP) is a rare, low-grade sarcoma with a tendency for recurrence. The overall annual incidence is 4.2 per million, or 0.1% of all cancers. It tends to affect young to middle-aged adults and occurs more often in blacks than in whites, with no sex predilection. Dermatofibrosarcoma presents as a flesh-colored, violaceous, or reddish-brown nodule with persistent bu...

Two cases of sarcoma of the heart, one of them being a round cell sarcoma, the other a rhabdomyosarcoma with fibrosarcomatous areas, are discussed. Studies of the histologic type, age and sex distribution, localization, general mode of growth and metastatic growth were made by reference to 225 cases reported in the international literature. Pertinent references are obtainable from the authors u...

Purpose: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous tumor. COL1A1–PDGFB gene fusion is frequent inDFSP, rendering tumor cell proliferation and survival dependent on PDGFRb (plateletderived growth factor receptor b) signaling. This trial investigated imatinib as neoadjuvant treatment of DFSP, including long-term follow-up. Experimental Design: The primary endpoint of this multice...

Three cell lines, spontaneously transformed in vitro, MWE-l and MWE-2 originating from C3Hf/Bi mouse whole embryos and NHLu-l originating from newborn syrian hamster lungs were obtained. These transformed cell lines were characterized by short generation time, marked aneuploidy in chromosome numbers and tumor induction in vivo. Histological appearance of the tumors induced by MWE-l was fibrosar...