BACKGROUND AND AIM To investigate the impact of a sustained virological response (SVR) to hepatitis C virus (HCV) treatment on liver stiffness (LS). METHODS LS, measured by transient elastography (FibroScan), demographic and laboratory data of patients treated with interferon (IFN)-containing or IFN-free regimens who had an SVR24 (undetectable HCV viral load 24 weeks after the end of treatmen...

BACKGROUND/AIM Transient elastography (TE) of liver and hepatic venous pressure gradient (HVPG) allows accurate prediction of cirrhosis and its complications in patients with chronic liver disease. There is no study on prediction of minimal hepatic encephalopathy (MHE) using TE and HVPG in patients with cirrhosis. PATIENTS AND METHODS Consecutive cirrhotic patients who never had an episode of...

BACKGROUND Liver biopsy and virological end points are standard references for assessing the effect of viral hepatitis treatments. We aimed to review evidence-based published data of biomarkers that have been validated as non-invasive alternatives to biopsy as end points for HBV and HCV infection trials. METHODS Studies were included if there were at least two repeated estimates of fibrosis p...

The staging of hepatic fibrosis is a cornerstone of prognosis and assessment of disease progression in those with chronic liver diseases including nonalcoholic steatohepatitis (NASH). This is so because a histological assessment of fibrosis has been the only clinically applicable readout of such progression over the last century. The last ten years have, however, seen numerous changes that have...

Background: five clinical phases were described in patients with chronic (HBV) infection: HBeAg- positive HBV infection, CHB, HBeAg negative HBeAg-negative CHB and occult infection.
 Aim: This study aimed to determine the incidence of unclassified phase (gray zone) hepatitis B its significant practice. 
 Patients methods: The was conducted retrospectively on 109 patients' who have HBs...

Hemophagocytic lymphohistiocytosis (HLH) is the result of excessive cytokine release, leading to over-response by immune cells, such as macrophages and T lymphocytes. Here, we report a lethal case of HLH with a complete clinical course. The patient was a 45-year-old man with fever and chills since two months ago plus splenomegaly, hepatomegaly, and pancytopenia. The Anti-HBc IgM was positive, b...

The liver fibrosis index (LFI), based on real‑time tissue elastography (RTE), is a method currently used to assess liver fibrosis. However, this method may not consistently distinguish between the different stages of fibrosis, which limits its accuracy. The aim of the present study was to develop novel models based on biochemical, RTE and ultrasound data for predicting significant liver fibrosi...