A 64-year-old diabetic lady underwent pars plana vitrectomy in her left eye for a taut posterior hyaloid face due to proliferative diabetic retinopathy (PDR). Visual acuity (VA) at baseline had been 20/120. She had previously received panretinal laser photocoagulation (PRP) and the retinopathy had been stable, but there was localized extrafoveal tractional retinal detachment in the inferonasal ...

Congenital fibrovascular pupillary membrane (1-4) is an unilateral ocular change of the anterior segment (Figure 1). This abnormality was first reported by Cibis et al. in 1986. In some cases, progressive miosis, posterior embryotoxon and abnormality of the anterior chamber angle have been documented. Pupillary membrane might not be adhered to crystalline, or it can also be associated with ante...

ATP-dependent glucokinase is suggested to have evolved from a hypothetical polyphosphate (polyP)-dependent glucokinase (polyP-GK) via a bifunctional polyP/ATP glucokinase (polyP/ATP-GK). Here we showed that polyP-GK is present in a polyP-accumulating bacterium, Microlunatus phosphovorus. The polyP-GK produced glucose-6-P(i) from glucose and polyP, but it could not phosphorylate glucose with ATP...

the pathogenetic mechanism of nasal polyps remains unknown, although allergy has been cited as an important factor in the etiology of nasal polyposis. currently there is no definite histological criterion for differentiation of allergic from inflammatory nasal polyp. however, in a few studies, tissue eosinophil count has been used for this. this study aimed to find out the agreement rate of ski...

BACKGROUND To evaluate the short-term efficacy of intravitreal injections of aflibercept (IVA) to treat retinal angiomatous proliferation (RAP) and identify factors related to functional outcomes. METHODS This retrospective case series consisted of 19 eyes in 19 patients with RAP. All 19 eyes received 3 monthly consecutive IVA. The primary outcome measures were best-corrected visual acuity (B...

A patient with human immunodeficiency virus infection and cytomegalovirus (CMV) retinitis developed immune recovery uveitis as a result of receipt of highly active antiretroviral therapy. Fibrovascular changes occurred in the CMV retinitis scar, were misdiagnosed as CMV retinitis reactivation, and were treated with anti-CMV medication. Fibrovascular membranes can be misdiagnosed as reactivated ...

Ischaemic diabetic retinopathy may be complicated by multiple outgrowths of fibrovascular tissue on to the retinal surface within the most cortical part of the vitreous gel, typically along the major vascular arcades and nasal to the optic disc. Tangential traction, exerted by contraction of the coalescent epiretinal membranes, results in distortion, folding, and detachment of the underlying re...

Polyphosphate (polyP) binds to fibrin(ogen) and alters fibrin structure, generating a heterogeneous network composed of 'knots' interspersed by large pores. Here we show platelet-derived polyP elicits similar structural changes in fibrin and examine the mechanism by which polyP alters fibrin structure. Polymerisation of fibrinogen with thrombin and CaCl2 was studied using spinning disk confocal...

Inorganic polyphosphate (PolyP) is a biological polymer that plays important roles in the cell physiology of both prokaryotic and eukaryotic organisms. Among the available methods for PolyP localization and quantification, a 4',6-diamidino-2-phenylindole(DAPI)-based assay has been used for visualization of PolyP-rich organelles. Due to differences in DAPI permeability to different compartments ...