The mdm2 oncogene encodes p90(MDM2), which binds to and inactivates the p53 tumor suppressor protein. p90(MDM2) inhibits p53 by blocking the transcriptional activation domain of p53 as well as by stimulating its degradation. Recently, we showed that another product of the wild-type mdm2 gene, p76(MDM2), lacks the first 49 amino acids of p90(MDM2) and cannot bind p53. Here, we report that, like ...

The ataxia telangiectasia mutated- and rad3-related kinase (ATR)/Chk1 pathway is a sentinel of cell cycle progression. On the other hand, the Ras/mitogen-activated protein kinase/90-kDa ribosomal S6 kinase (p90 RSK) pathway is a central node in cell signaling downstream of growth factors. These pathways are closely correlated in cell proliferation, but their interaction is largely unknown. Here...

objectives: this study aimed to evaluate the effects of chlorhexidine mouthrinses on color stability of nanofilled and micro-hybrid resin-based composites. materials and methods: in this in-vitro study, 160 disc-shaped specimens (7x2mm) were fabricated of filtek z250 and filtek z350xt enamel (a2 shade). the samples of each group were randomly divided into eight subgroups (n=10). the specimens w...

AIM The study aims to evaluate and compare total gap surface area formed after restoration of class II cavities with Filtek Z350 and P60 at room temperature, 37°C and 54°C. MATERIALS AND METHODS Thirty extracted maxillary and mandibular molars were taken and divided into six groups of five teeth each. Standardized class II cavities were made and were restored with Filtek Z350 and P60, both at...

The aim of this study was to compare the shrinkage stress of composite resins by three methods. In the first method, composites were inserted between two stainless steel plates. One of the plates was connected to a 20 kgf load cell of a universal testing machine (EMIC-DL-500). In the second method, disk-shaped cavities were prepared in 2-mm-thick Teflon molds and filled with the different compo...

OBJECTIVE To investigate the mechanical properties of different classifications of composites indicated for posterior application as functions of the storage condition and of the energy dose. MATERIAL AND METHODS Specimens (8 x 2 x 2 mm) were obtained according to the factors: I) Composites (3M ESPE): Filtek P60, Filtek Z350XT, and Filtek Silorane; II) Syringe storage conditions: room tempera...

Objectives The aim of the study was to evaluate the 5-year clinical performance of occlusal carious restorations using nanofill and microhybrid composites, in combination with 3-step etch-and-rinse adhesives, in patients who were going to commence orthodontic treatment. Materials and Methods A total of 118 restorations for occlusal caries were conducted prior to orthodontic treatment. Occlusa...

Received: 27 April 2013 Accepted: 6 August 2013 Abstract Background and Aim: Discoloration is among the most common problems of composite restorations. Color change over time compromises the main advantage of composite resins namely their high esthetics. In such cases, the restoration needs to be replaced. .The aim of this in-vitro study was to evaluate the effect of accelerated artificial agin...

Objectives: The aim of this investigation was to assess the influence of different surface treatments and repair material on the repair shear bond strength (SBS) of GC Fuji IX GP Packable Posterior Restorative, Filtek Bulk Fill, and Filtek Supreme Ultra Flowable. Methods: Thirty cylindrical specimens were prepared from each material and randomly allocated into 3 groups/10 each. Group 1: no surf...