BACKGROUND Despite dramatic improvements in the management of burns, infection still remains a serious risk for the burn patient. The aim of this study was to shed light on the impact of acute burn injury with or without infection on cytokine profiles. METHODS Sprague-Dawley rats (n = 21) were randomized into three groups: 1) burn only 2) burn and infection or 3) sham burn. Weight was monitor...

BACKGROUND The face is a frequent site of burn, but prevalence rates vary and reports are often limited to one healthcare setting. We examined the incidence of facial burns in the Netherlands in Emergency Departments (ED), hospitals and burn centres. Additionally, we identified which patient, injury and burn-related characteristics were predictors of facial burns, facial surgery and facial reco...

Thermal trauma is associated with cardiac myocyte apoptosis in vivo. To determine whether cardiac myocyte apoptosis could be secondary to burn-induced cytokines or inflammatory mediators, we investigated the effects of tumor necrosis factor-alpha (TNF-alpha) and burn plasma on a murine cardiac myocyte cell line and primary culture myocytes. HL-1 cells were exposed to plasma isolated from burned...

4,547 burn patients from 1983-1993 were reviewed by analysing the general data, mortality, and the causes of the death, and the mortality of 606 burn patients in different periods from 1958 to 1993. The purpose was to present some statistical and epidemiological data. The results showed: The incidence of burn injury in children, whose ages were less than 5 years, reached 36.2%, and the causes o...

BACKGROUND Advances in the care of burn injuries have resulted from the efforts of regional patient-based specialist teams at burn care centers. OBJECTIVES We conducted this study to assess the four-year epidemiology of burn injuries in Rasht, Iran. MATERIALS AND METHODS In this cross-sectional study, medical records of 2274 burn patients, treated at Velayat hospital from January 2007 to De...

The mortality of burn patients remains high in spite of the advances made in treating initial burn shock, controlling burn wound infection, and providing nutritional support. Smoke inhalation is recognized as a strong determinant of morbidity and mortality in burn patients, and most burn patients die because of associated inhalation injury. There are many reports on this combined injury (cutane...

OBJECTIVE To perform a systematic exploration of the phenomenon of mobilization of circulating angiogenic cells (CACs) in an animal model. This phenomenon has been observed in patients with cutaneous burn wounds and may be an important mechanism for vasculogenesis in burn wound healing. DESIGN We used a murine model, in which burn depth can be varied precisely, and a validated culture method ...

Burn injuries in both developed and developing countries cause long-term disability, mortality, and socio-economic costs that are imposed on patients, families, and societies. This study was carried out to investigate the epidemiology, outcome, and cost of hospitalization of 388 burn patients admitted to the Imam Khomeini Hospital Burn Center in Kermanshah, Iran, between 21 March 2011 and 20 Ma...

Each year more than 300 000 people die from fire-related burn injuries. Millions more suffer from burn-related disabilities and disfigurements which have psychological, social and economic effects on both the survivors and their families. The burden of burn injury is one that falls predominantly on the world’s poor: 95% of fire-related burn deaths occur in lowand middle-income countries (LMICs)...

Over the last two decades burn mortality rates have declined (Table I) due to the development of new treatment modalities. The advances that have led to decreased mortality rates in burn patients have evolved from ongoing research of new therapies that improve long-term outcome. In 1952, a 50 per cent total body surface area burn victimized nearly one-half of young patients under 17 years of ag...