Among angiosarcomas, radiation-induced breast sarcomas (RIBS) represent a well-known entity generally characterized by a poor outcome, especially in patients with advanced disease. Despite the unfavorable prognosis, some chemotherapeutic agents have been used to treat these malignancies, occasionally with success. Treatments with demonstrated activity against sarcomas include ifosfamide-based r...

This study was to evaluate the long-term efficacy and safety of a single-dose rituximab regimen rituximab treatment in adult patients with steroid-dependent minimal change nephrotic syndrome (MCNS). We conducted a prospective cohort study with historical controls to evaluate the effect of single-dose infusions of rituximab at 375 mg/m2 BSA per dose administered at intervals of 6 months for a pe...

objective: infantile spasms (is) is an age specific epileptic syndrome. due to poor response of is to conventional antiepileptic drugs, scientists are always on the lookout for newer, more effective drugs to treat the condition. materials & methods: in this study, 50 infants with is symptoms, aged between 2-24 months, were randomly divided into two equal groups, each treated either with vigabat...

Flow cytometric analyses of bone marrow cellular DNA content were performed in 1 1 5 adult patients with acute leukemia to assess whether and how proliferative activity relates to other disease and host parameters, to antileukemic effect of induction chemotherapy. and to patient prognosis. Eighty previously untreated patients had a smaller S-phase compartment than patients with morphologically ...

The likelihood of pathological complete remission (pCR) of breast cancer following neoadjuvant chemotherapy (NACT) is increasing; most of all in the triple negative and HER2 positive tumour subgroups. The question thus arises whether or not breast surgery is necessary when there is complete remission after NACT, and whether it provides any improvement of the oncological treatment result when tu...

BACKGROUND Neurolymphomatosis (NL) is an extremely rare disease and tracheal asphyxia due to NL has not been previously reported. CASE PRESENTATION A 54-year-old Chinese woman with a history of diffuse large B-cell lymphoma in her first complete remission developed peripheral neuropathy and tracheal asphyxia. Neurolymphomatosis involving the right brachial plexus and the right vagus nerve was...

FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) mutations are among the most frequent molecular aberrations in patients with acute myeloid leukemia. We retrospectively analyzed 324 patients with acute myeloid leukemia treated with front-line induction chemotherapy between October 2004 and March 2010. Fifty-six patients had FLT3-ITD mutation at diagnosis. Fifty-one (91%) patien...

Patient Selection Criteria Coverage eligibility will be considered for allogeneic hematopoietic cell transplant (allo-HCT) using a myeloablative conditioning (MAC) regimen to treat acute myeloid leukemia (AML) when ANY of the following criteria are met:  Poorto intermediaterisk acute myeloid leukemia (AML) in first complete remission (CR1) (see Policy Guidelines section for information on risk...