Since the development of monoclonal antibodies twenty-five years ago, researchers and biotech companies have been looking to develop therapeutic uses for them. Michael Gross looks at some of the latest efforts.

The majority of the persons in this book had the advantage of being born and raised in centers of civilization, highly cultured or politically pivotal nations. Muhammad, however, was born in the year 570, in the city of Mecca, in southern Arabia, at that time a backward area of the world, far from the centers of trade, art, and learning. Orphaned at age six, he was reared in modest surroundings...

This case study of truancy in Coventry puts into a local context a national phenomenon of considerable concern to local authorities in the last quarter of the nineteenth century. The records of parents prosecuted for their child's truancy over a twenty-five year period provided the data for analysis. It was possible to produce a profile of the truants and their families within the socio-economi...

background: historically open surgical drainage has been the treatment of choice for pyogenic liver abscess. the records of 54 patients with pyogenic liver abscess were reviewed to determine whether earlier diagnosis with current imaging tests and definitive treatment with antibiotics and aspiration drainage was an effective alternative to surgery. methods: the clinical features, laboratory tes...

background: the treatment of open tibial fractures is still an orthopaedic challenge and full of complications. in many cases the use of external fixator that has been known as a non-:union: machine is obligatory with a high incidence of pin track infection and other complications. the aim of this study was to compare the use of external fixation as a definite method for treatment of open tibia...

BACKGROUND A five-level version of the EuroQol five-dimensional (EQ-5D) descriptive system (EQ-5D-5L) has been developed, but value sets based on preferences directly elicited from representative general population samples are not yet available. The objective of this study was to develop values sets for the EQ-5D-5L by means of a mapping ("crosswalk") approach to the currently available three-l...

BACKGROUND The EQ-5D is a brief, generic measure of health status that can be easily incorporated into population health surveys. There are two versions of the EQ-5D for use in adult populations, one with 3 response levels in each of the instrument's 5 dimensions (EQ-5D-3L) and one with 5 levels in each dimension (EQ-5D-5L). We compared the two versions as measures of self-reported health statu...

the main goal of this paper is to introduce and study a new class of function via the notions of $e$-$theta$-open sets and $e$-$theta$-closure operator which are defined by özkoç and aslım cite{10} called weakly $er$-open functions and $e$-$theta$-open functions. moreover, we investigate not only some of their basic properties but also their relationships with other types of already existing to...

BACKGROUND Some studies have reported a ceiling effect in EQ-5D-3L, especially in healthy and/or young individuals. Recently, two further levels have been included in its measurement model (EQ-5D-5L). The purposes of this study were (1) to assess the properties of the EQ-5D-5L in comparison with the standard EQ-5D-3L in a sample of young adults, (2) to foreground the importance of collecting qu...