This study focuses on the molecular level interpretation of the selective gas-phase cleavage at aspartic acid residues (Asp) in protonated peptides. A phi3P+CH2C(=O)group (phi = 2,4,6-trimethoxyphenyl) is attached to the N-terminal nitrogen of the selected peptides LDIFSDF and LDIFSDFR, via solid-phase synthesis, to "mimic" the tightly held charge of a protonated arginine (Arg) residue. Collisi...

This paper presents two variants of genetic algorithm for solving the Supply Management Problem, which can be viewed as a generalization of the Fixed Charge Transportation Problem. The first variant uses the usual binary representation of solutions. The second one is based on the permutation representation and the greedy decoder. Computational results indicate good performance of the second app...

This paper presents a numerical calculation of the evolution of the spatially resolved solid concentration in the two electrodes of a lithium-ion cell. The microscopic solid concentration is driven by the macroscopic Butler–Volmer current density distribution, which is consequently driven by the applied current through the boundary conditions. The resulting, mostly causal, implementation of the...

The focus of our research is on rail transportation of intermodal containers. We address the problem of determining day-of-week schedules for both direct and indirect (via a hub) trains and allocating containers to these trains for the rail (linehaul) portion of the intermodal trip. The goal is to minimize operating costs, including a fixed charge for each train, variable transportation and han...

In this paper we use a specialized version of our pivot and probe algorithm to solve generalized transportation problems with side constraints. The dual of an m x n generalized transportation problem with t side constraints is a linear program with m + n + t variables and up to m x n constraints. We solve the dual problem using the probe operation to select only the most important constraints t...

The solid component of the tectorial membrane (TM) is a porous matrix made up of the radial collagen fibers and the striated sheet matrix. The striated sheet matrix is believed to contribute to shear impedance in both the radial and longitudinal directions, but the molecular mechanisms involved have not been determined. A missense mutation in Tecta, a gene that encodes for the α-tectorin protei...

In this study criterion of maximum profit intensity for transportation problems, in contrast to the known criteria of minimum expenses or minimum time for transportation, is considered. This criterion synthesizes financial and time factors and has real economic sense. According to the purpose of this paper, the algorithm of the solution of such a transportation problem is constructed. It is sho...