Floating drug delivery systems (FDDS) are utilized to target discharge in the stomach or upper parts of intestine. Famotidine has been most extensively used for management peptic ulcer various decades. The current study concerns development and evaluation floating tablets famotidine which, after oral administration, planned extend gastric residence time, enhance bioavailability aim ulcer. A FDD...

This learning's objective is to determine and investigate how pharmaceutical restrictions affect the characteristics of gastric floating tablets using diclofenac sodium (DICL) as a model for solubility enhancement, sodium-bicarbonate (NaHCO3) or calcium-carbonate (CaCO3). Hydroxypropyl Methylcellulose (HPMC) swelling polymer K100M K15M gas-forming substance. BY direct-compression manufacturing ...

During the past two decades, the identification of new scientific developments to improve outcomes in gastrointestinal disorders has been attractive to many researchers. Pharmaceutical industries are now more motivated to introduce novel therapeutic remedies in the treatment of gastrointestinal disorders. Such disorders have increased at an exponential rate in various patient communities and bo...

The objective of the present investigation was to design a sustained release floating microcapsules of theophylline using two polymers of different permeability characteristics; Eudragit RL 100 (Eu RL) and cellulose acetate butyrate (CAB) using the oil-in-oil emulsion solvent evaporation method. Polymers were used separately and in combination to prepare different microcapsules. The effect of d...

The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer. FAM was prepared as freeze-dried floating alginate beads using ion gelation method and then coated with Eudragit RL100 to sustain FAM release. QRT was prepared as solid dispersion with polyvinyl pyrrolidone K30 to improve its solubility. Photo images and...

Hypertension, or high blood pressure, is a major public health concern around the world because of its large contribution to global burden and function as risk factor for variety disease processes. Bosentan SR Floating Bilayer Tablets were made with HPMC K4M, E-15, E-15 alone (80%) in combination varying percentages polymer (20&60 percent, 40&40 60&20 percent ). The hydrophilic used...