plant-derived natural products are known to have cancer chemo-preventive and chemo-therapeutic properties. plant extracts or their active constituents are used as folk medicine in traditional therapies by 80% of the world population. the aim of the present study was to determine the anti-proliferative potential of fumaria vaillantii extracts on three different cancer cell lines including malign...

BACKGROUND: Semen cryopreservation might be influenced by sperm concentration. OBJECTIVES: This study was conducted to investigate three different semen concentrations [100 (C100), 50 (C50), and 25 (C25) × 106 spermatozoa/mL] on freezability of bull semen. METHODS: On each collection day, four ejaculates were collected (a total of 24 ejaculates from four bulls), pooled and divided to three equ...

there exists compelling evidence that toll-like receptor 3 (tlr3) agonists can directly affect human cancer cells. the aim of this study was to investigate anti-cancer effects of tlr3 agonist in human breast cell line. we assessed potential effects of poly (a:u) on human breast cell line (mda-mb-231)  on a dose-response and time-course  basis. human breast cell line  mda-mb-231  was treated wit...

Background: Researches towards Glioblastoma multiforme therapy (GBM) has been performed, especially in finding the tumor’s genetic cellular expression. The overexpression of EGFR, frequently found human malignancies, is known to significantly impact cancer cells hallmark traits, such as increased cell survival, proliferation and invasion. This research performed figure out synergistic effect te...

Background and Aim of Study: There are two different phases untreated chronic myeloid leukemia – phase, blast crisis according to the World Health Organization classification Hematolymphoid tumors. The cells in can express myeloid, lymphoid, bi-phenotypic, monocytic, megakaryocytic, erythroid phenotypes. immunophenotype population determines how patients respond treatment, hence flowcytometric ...

Aesculetin is an active member of coumarins that has been reported to possess significant medicinal and biological importance. It also shown with potential anticancer activity against different human cancers including breast, lung hepatocellular carcinoma. Therefore, the current investigation was undertaken examine effects aesculetin gastric cancer. MTT assay performed check cellular viability ...

Background: Inappropriate activation or blockage of the inhibition of complement system could cause tissue damages in autoimmune diseases particularly rheumatoid arthritis (RA). Defect in complement component regulation may cause damages to tissues, on the other hand, or the damaged tissue might affect the unnecessary activation of complement components.   Objective: To investigate the expressi...

BACKGROUND Genetic modifications can improve the therapeutic efficacy of mesenchymal stem cell (MSC) transplantation in myocardial infarction. However, so far, the efficiency of MSC modification is very low. Seeking for a more efficient way of MSC modification, we investigated the possibility of employing the intercellular trafficking capacity of the herpes simplex virus type-1 tegument protein...