introduction: several studies have indicated that late treatment of aminoguanidine (ag) reduces cerebral ischemic injuries in animal models. however, the effects of early treatment of ag on cerebral ischemic damage are not well understood. this study was designed to evaluate effect of early treatment of ag on cortex and striatum injuries as well as neurological dysfunctions in transient model o...

Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activation of phosphoinositide 3-kinase, p38 MAPK (mitogen-activated protein kinase) an...

α-Actinins (ACTNs) are known to crosslink actin filaments at focal adhesions in migrating cells. Among the four isoforms of mammalian ACTNs, ACTN1 and ACTN4 are ubiquitously expressed. Recently, ACTN4 was reported to enhance cancer cell motility, invasion, and metastasis. However, the mechanism by which ACTN4 drives these malignant phenotypes remains unclear. Here, we show that ACTN4, but not A...

P-wave first-motion polarity is important for the inversion of earthquake focal mechanism solutions. The solution can further contribute to our understanding source rupture process, fault structure, and regional stress field characteristics. By using abundant solutions small moderate earthquakes, we deepen geometry seismogenic environment. In this paper, propose an automatic workflow, FocMech-F...

In n-player games a focal player may choose n− 1 players to play a round of the game. It makes sense that this choice might be informed, meaning that the focal player tries to choose the best n− 1 players from the population. Reputation is a mechanism that allows such informed choice. In this paper we present a private reputation mechanism that can be applied to any n-player game. Our solution ...

occupational exposure to heavy metals, organic solvents and silica is associated with a variety of renal manifestations. improved understanding of occupational renal disease provides insight into environmental renal disease, improving knowledge of disease pathogenesis. silica (sio 2 ) is an abundant mineral found in sand, rock, and soil. workers exposed to silica include sandblasters, miners, q...

we report two cases of focal nodular hyperplasia in patients following gadoxetic acid (gd-eob-dtpa)-enhanced magnetic resonance imaging confirmed with histopathology. these cases showed an atypical pattern during the delayed-hepatobiliary phase after the injection of gadoxetic acid. one case showed a total defect, and the other showed a peripheral ring-like enhancement without a visible central...

focal epithelial hyperplasia (feh) or heck’s disease is a rare viral infection of the oral mucosa caused by human papilloma virus especially subtypes 13 or 32. the frequency of this disease varies widely from one geographic region and ethnic groups to another. this paper reports an iranian case of extensive focal epithelial hyperplasia. a 35-year-old man with feh is described, in whom the lesio...