ing hormone and follicle stimulating hormone with a low oestradiol concentration confirm menopausal status. In peri­ menopause, some menstrual bleeding may still be occurring, and luteinising hormone, follicle stimulating hormone and oestradiol may be normal, or only follicle stimulating hor­ mone may be raised. If there is any doubt about perimeno­ pausal status, blood tests should be repeated...

Antral follicular growth in the ovary is characterized by rapid expansion of granulosa cells accompanied by a rising complexity of their functionality. Within two weeks the number of human granulosa cells increases from less than 500,000 to more than 50 millions cells per follicle and differentiates into groups of cells with a variety of specialized functions involved in steroidogenesis, nursin...

Spermatogenesis is regulated by the 2 pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is considered impossible without the absolute requirement of LH-stimulated testicular testosterone (T) production. The role of FSH remains unclear because men and mice with inactivating FSH receptor (FSHR) mutations are fertile. We revisited the role of FS...

Spermatogenesis is thought to critically depend on the high intratesticular testosterone (T) levels induced by gonadotropic hormones. Strategies for hormonal male contraception are based on disruption of this regulatory mechanism through blockage of gonadotropin secretion. Although exogenous T or T plus progestin treatments efficiently block gonadotropin secretion and suppress testicular T prod...

In this report, we review our present effort in the field of molecular reproductive endocrinology: to identify a small molecular weight follicle stimulating hormone (FSH) agonistic molecule. To achieve this goal we require a number of molecular tools. We have cloned and expressed the human gonadotrophin, FSH and the human FSH receptor and developed a reliable high throughput assay. We have also...

Abstract. Setyorini YW, Kurnianto E, Sutopo, Sutiyono. 2023. Identification polymorphism of LHR and FSHR genes in Indonesian Holstein dairy cattle associated with productive reproductive traits. Biodiversitas 24: 2898-2905. Luteinizing follicle-stimulating hormones their receptors play an important role the system’s hormonal activity physiological function. This study aimed to identify genotype...

The use of progesterone for luteal support in stimulated cycles for in-vitro fertilization is well established. However, the benefits of the addition of estradiol are still controversial. The aim of this study was to compare ongoing pregnancy rates in patients stimulated with recombinant follicle stimulating hormone and gonadotrophin releasing hormone antagonist for in vitro fertilization, who ...