OBJECTIVE Subclinical inflammation is an important risk factor for type 2 diabetes and diabetes complications. However, data on the association between inflammation and acute diabetic foot syndrome are scarce. The aim of this study was to compare systemic immune mediators in diabetic patients with and without an ulcer and to identify modulating factors. RESEARCH DESIGN AND METHODS Circulating l...

OBJECTIVE To compare patient outcomes 1 year before and 1 year after enrollment in a comprehensive diabetes lower-extremity amputation prevention program. RESEARCH DESIGN AND METHODS Outcome data were obtained on 197 patients enrolled in the Louisiana State University Health Sciences Center Diabetes Foot Program, which provides foot care to a predominantly low-income African-American populati...

Diabetic foot ulcer classification systems use the presence of wound infection (bacteria present within wound) and ischaemia (restricted blood supply) as vital clinical indicators for treatment prediction healing. Studies investigating automated computerised methods classifying diabetic wounds are limited due to a paucity publicly available datasets severe data imbalance in those few that exist...

This issue of Seminars in Vascular Surgery is devoted to the evaluation and management of lower-limb wounds in the vascular surgery patient. In-depth discussions of common clinical conditions are presented on the topics of venous ulcer, diabetic foot infection, peripheral arterial disease (PAD) with tissue loss, and surgical site infection (SSI). The first article by Scalise et al discusses the...

BACKGROUND Australia is ranked ninth of 39 countries in the Western Pacific region most affected by diabetes. Patients with diabetes are at high risk of developing foot ulcerations that can develop into non-healing wounds. Recent studies suggest that the lifetime risk of developing a diabetic foot ulcer is as high as 25%. Few studies have reported the prevalence of, risk factors and socioeconom...

OBJECTIVE The purpose of this study was to determine whether a strategy of aggressive cardiovascular risk management reduced the mortality associated with diabetic foot ulceration. RESEARCH DESIGN AND METHODS After an initial audit of outcomes demonstrating a high mortality rate in 404 diabetic foot ulcer patients with the first ulceration developing between 1995 and 1999, a new aggressive ca...

OBJECTIVE To compare risks of lower-extremity amputation between patients with Charcot arthropathy and those with diabetic foot ulcers. RESEARCH DESIGN AND METHODS A retrospective cohort of patients with incident Charcot arthropathy or diabetic foot ulcers in 2003 was followed for 5 years for any major and minor amputations in the lower extremities. RESULTS After a mean follow-up of 37 +/- ...

Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mel...

Diabetic Foot Ulcer (DFU) is a complication of Diabetes Mellitus (DM), which major health problem throughout the world with high recurrence rate. It estimated that approximately 40% patients have within one year ulcer healing, nearly 60% three years, and 65% five years. One efforts to prevent DFU can be made foot care preceded by knowledge care. This study aimed compare before after being given...

BACKGROUND Chronic planter ulcer, also known as trophic ulcer, shows no tendency towards healing. It is usually seen in sensory deficient foot. The clinical result of a sensory, motor or autonomic loss of a nerve function is frequently the same--ulceration, although the exact cause may vary. The treatment principle involves dressing and avoiding pressure on the ulcerated site called 'offloading...