The analysis and profiling of short tandem repeat (STR) loci is routinely used in forensic genetics. Current methods to investigate STR loci, including PCR-based standard fragment analyses and capillary electrophoresis, only provide amplicon lengths that are used to estimate the number of STR repeat units. These methods do not allow for the full resolution of STR base composition that sequencin...

Detection and identification of human body fluids represent very important aspects of forensic biology, since in the case of numerous offences, a firm determination of the DNA source (e.g. semen, saliva, epithelium) rather than establishing the DNA profile alone is of great significance. The presently employed routine methods are insufficient: there are no specific tests confirming the presence...

One of the most important inventions and development in history human race is forensic science. Without having knowledge science, there would be a great negative effect on society as well judicial system. In contemporary era, science play very role solving crime problem. It provides better opportunities to system for detection criminal. The present India comprise various modes techniques includ...

We describe a novel method for rapidly identifying and distinguishing between different DNA sequences using short tandem repeat (STR) analysis and DNA microarrays. The method can be used to deduce identity, length, and number of STRs of the target molecule. We refer to this technique as the "variable-length probe array" method for STR profiling (VLPA). The method involves hybridization of the u...

The traditional manual approach to the investigation of digital data is no longer feasible as the amount of data which can be saved on hard drives grows out of control. In addition, it is usually necessary to consider data across extensive networks of devices in order to obtain a realistic picture of an investigation and ensure that no evidence is overlooked. The need for an automated approach ...

DNA methylation is emerging as an attractive marker providing investigative leads to solve crimes in forensic genetics. The identification of body fluids that utilizes tissue-specific DNA methylation can contribute to solving crimes by predicting activity related to the evidence material. The age estimation based on DNA methylation is expected to reduce the number of potential suspects, when th...

In forensic genetics mitochondrial DNA (mtDNA) is usually analyzed by direct Sanger-type sequencing (STS). This method is known to be laborious and sometimes prone to human error. Alternative methods have been proposed that lead to faster results. Among these are methods that involve mass-spectrometry resulting in base composition profiles that are, by definition, less informative than the full...

Over the past 25 years, DNA technology has become a cornerstone of criminal investigations across the globe. In Genetic Suspects, a series of essays seeks to address the key issues surrounding the use of DNA technology in forensics, expounding on scientific, legal, and social concerns. The book is written for a specialized audience, as is stated on the back cover ― specifically those with scien...

We describe a flexible computational toolkit, based on object-oriented Bayesian networks, that can be used to model and solve a wide variety of complex problems of relationship testing using DNA profiles. In particular this can account for such complicating features as missing individuals, mutation and null alleles. We illustrate the use of this toolkit with several examples, including disputed...

Forensics profiling refers to the study and exploitation of traces in order to draw a profile relevant to the investigation about criminal or litigious activities. While traces may not be strictly dedicated to a court use, they may increase knowledge of the subject under investigation. In this context we will study the evidence found in a modern ebook reader, and we will explain how it could be...